Diagnostic accuracy of chest computed tomography scans for suspected patients with COVID-19: Receiver operating characteristic curve analysis

Lianpin Wu, Qike Jin, Jie Chen, Jiawei He, David M. Brett-Major, Jianghu James Dong

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Computed tomography (CT) scans are increasingly available in clinical care globally. They enable a rapid and detailed assessment of tissue and organ involvement in disease processes that are relevant to diagnosis and management, particularly in the context of the COVID-19 pandemic. Objective: The aim of this paper is to identify differences in the CT scan findings of patients who were COVID-19 positive (confirmed via nucleic acid testing) to patients who were confirmed COVID-19 negative. Methods: A retrospective cohort study was proposed to compare patient clinical characteristics and CT scan findings in suspected COVID-19 cases. A multivariable logistic model with LASSO (least absolute shrinkage and selection operator) selection for variables was used to identify the good predictors from all available predictors. The area under the curve (AUC) with 95% CI was calculated for each of the selected predictors and the combined selected key predictors based on receiver operating characteristic curve analysis. Results: A total of 94 (56%) patients were confirmed positive for COVID-19 from the suspected 167 patients. We found that elderly people were more likely to be infected with COVID-19. Among the 94 confirmed positive patients, 2 (2%) patients were admitted to an intensive care unit. No patients died during the study period. We found that the presence, distribution, and location of CT lesions were associated with the presence of COVID-19. White blood cell count, cough, and a travel history to Wuhan were also the top predictors for COVID-19. The overall AUC of these selected predictors is 0.97 (95% CI 0.93-1.00). Conclusions: Taken together with nucleic acid testing, we found that CT scans can allow for the rapid diagnosis of COVID-19. This study suggests that chest CT scans should be more broadly adopted along with nucleic acid testing in the initial assessment of suspected COVID-19 cases, especially for patients with nonspecific symptoms.

Original languageEnglish (US)
Article numbere19424
JournalJMIR Public Health and Surveillance
Volume6
Issue number4
DOIs
StatePublished - Oct 2020

Keywords

  • AUC
  • COVID-19
  • Chest CT scans
  • Nucleic acid testing
  • ROC
  • Retrospective cohort study

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health Informatics

Fingerprint

Dive into the research topics of 'Diagnostic accuracy of chest computed tomography scans for suspected patients with COVID-19: Receiver operating characteristic curve analysis'. Together they form a unique fingerprint.

Cite this