TY - JOUR
T1 - Diagnostic accuracy of coronary computed tomography angiography in ischemic workup of heart failure
T2 - A meta-Analysis
AU - Tiwari, Nidhish
AU - Nagraj, Sanjana
AU - Tzoumas, Andreas
AU - Arfaras-Melainis, Angelos
AU - Katamreddy, Adarsh
AU - Sohal, Sumit
AU - Palaiodimos, Leonidas
N1 - Publisher Copyright:
© 2022 Future Medicine Ltd.
PY - 2022/4
Y1 - 2022/4
N2 - Aim: The role of coronary computed tomography angiography (CCTA) in evaluating the etiology of heart failure with reduced ejection fraction (HFrEF) is unclear. This is a meta-Analysis assessing the pooled diagnostic accuracy of CCTA in diagnosing significant coronary artery disease in HFrEF. Materials & methods: Electronic databases were searched for studies comparing CCTA with invasive coronary angiography in HFrEF. A random-effects model meta-Analysis was conducted. Results: Five studies comprising 269 patients were included. On patient-based analysis, pooled sensitivity and specificity of CCTA were 0.99 (95% CI: 0.94-1.00) and 0.94 (95% CI: 0.90-0.97), respectively. On segment-based analysis, pooled sensitivity and specificity were 0.74 (95% CI: 0.67-0.80) and 0.99 (95% CI: 0.98-0.99), respectively. Conclusion: CCTA has excellent diagnostic accuracy in diagnosing significant coronary artery disease in newly diagnosed HFrEF.
AB - Aim: The role of coronary computed tomography angiography (CCTA) in evaluating the etiology of heart failure with reduced ejection fraction (HFrEF) is unclear. This is a meta-Analysis assessing the pooled diagnostic accuracy of CCTA in diagnosing significant coronary artery disease in HFrEF. Materials & methods: Electronic databases were searched for studies comparing CCTA with invasive coronary angiography in HFrEF. A random-effects model meta-Analysis was conducted. Results: Five studies comprising 269 patients were included. On patient-based analysis, pooled sensitivity and specificity of CCTA were 0.99 (95% CI: 0.94-1.00) and 0.94 (95% CI: 0.90-0.97), respectively. On segment-based analysis, pooled sensitivity and specificity were 0.74 (95% CI: 0.67-0.80) and 0.99 (95% CI: 0.98-0.99), respectively. Conclusion: CCTA has excellent diagnostic accuracy in diagnosing significant coronary artery disease in newly diagnosed HFrEF.
KW - coronary angiography
KW - coronary artery disease
KW - coronary computed tomography angiography
KW - heart failure
KW - ischemic cardiomyopathy
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U2 - 10.2217/fca-2021-0108
DO - 10.2217/fca-2021-0108
M3 - Article
C2 - 35118872
AN - SCOPUS:85127836102
SN - 1479-6678
VL - 18
SP - 325
EP - 335
JO - Future Cardiology
JF - Future Cardiology
IS - 4
ER -