TY - JOUR
T1 - Diagnostic performance of contrast-enhanced ultrasound in diagnosing hepatic artery occlusion after liver transplantation
T2 - A systematic review and meta-analysis
AU - Songtanin, Busara
AU - Brittan, Kevin
AU - Sanchez, Sebastian
AU - Le, Michelle
AU - Schmidt, Cynthia
AU - Ingviya, Thammasin
AU - Manatsathit, Wuttiporn
N1 - Publisher Copyright:
© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2023/11
Y1 - 2023/11
N2 - Introduction: Hepatic artery occlusion (HAO) is a significant complication post-liver transplantation. Doppler ultrasound (DUS) has been widely used as an initial screening test for detecting HAO; however, its performance is often not sufficient. Although other diagnostic tests such as computed tomography angiography (CTA), magnetic resonance angiography (MRA), and angiogram are more accurate, they are invasive and have several limitations. Contrast-enhanced ultrasound (CEUS) is an emerging tool for detecting HAO; however, the results from previous studies were limited due to a small number of patients. Therefore, we aimed to evaluate its performance by performing a meta-analysis. Method: We performed a systemic review and meta-analysis of studies evaluating the performance of CEUS for the detection of HAO in an adult population. A literature search of EMBASE, Scopus, CINAHL, and Medline was conducted through March 2022. Pooled sensitivity, specificity, log diagnostic odd ratio (LDOR), and area under summary receiver operating curve (AUC) were calculated. Publication bias was assessed by Deeks’ funnel plot. Result: Eight studies were included, with 434 CEUS performed. Using a combination of CTA, MRA, angiography, clinical follow-up, and surgery as the gold standard, the sensitivity, specificity, and LDOR of CEUS for detection of HAO were.969 (.938,.996),.991 (.981, 1.001), and 5.732 (4.539, 6.926), respectively. AUC was.959. The heterogeneity between studies appeared universally low, and no significant publication bias was found (p =.44). Conclusion: CEUS appeared to have an excellent performance for the detection of HAO and could be considered as an alternative when DUS is non-diagnostic or when CTA, MRA, and angiogram are not feasible.
AB - Introduction: Hepatic artery occlusion (HAO) is a significant complication post-liver transplantation. Doppler ultrasound (DUS) has been widely used as an initial screening test for detecting HAO; however, its performance is often not sufficient. Although other diagnostic tests such as computed tomography angiography (CTA), magnetic resonance angiography (MRA), and angiogram are more accurate, they are invasive and have several limitations. Contrast-enhanced ultrasound (CEUS) is an emerging tool for detecting HAO; however, the results from previous studies were limited due to a small number of patients. Therefore, we aimed to evaluate its performance by performing a meta-analysis. Method: We performed a systemic review and meta-analysis of studies evaluating the performance of CEUS for the detection of HAO in an adult population. A literature search of EMBASE, Scopus, CINAHL, and Medline was conducted through March 2022. Pooled sensitivity, specificity, log diagnostic odd ratio (LDOR), and area under summary receiver operating curve (AUC) were calculated. Publication bias was assessed by Deeks’ funnel plot. Result: Eight studies were included, with 434 CEUS performed. Using a combination of CTA, MRA, angiography, clinical follow-up, and surgery as the gold standard, the sensitivity, specificity, and LDOR of CEUS for detection of HAO were.969 (.938,.996),.991 (.981, 1.001), and 5.732 (4.539, 6.926), respectively. AUC was.959. The heterogeneity between studies appeared universally low, and no significant publication bias was found (p =.44). Conclusion: CEUS appeared to have an excellent performance for the detection of HAO and could be considered as an alternative when DUS is non-diagnostic or when CTA, MRA, and angiogram are not feasible.
KW - contrast enhanced ultrasound
KW - hepatic artery occlusion
KW - hepatic artery stenosis
KW - hepatic artery thrombosis
KW - liver transplantation
KW - ultrasound
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U2 - 10.1111/ctr.15070
DO - 10.1111/ctr.15070
M3 - Article
C2 - 37398993
AN - SCOPUS:85164333385
SN - 0902-0063
VL - 37
JO - Clinical Transplantation
JF - Clinical Transplantation
IS - 11
M1 - e15070
ER -