Guinea pigs were fed two different fat:CHO ratios: 2.5:58% (w/w) or 25:29% (w/w) with either sucrose or starch as the sole CHO source to determine the effects of CHO type and amount on specific sites of plasma VLDL and LDL metabolism Intake of high fat diets resulted in higher plasma LDL cholesterol levels (P < 0.01) while simple CHO increased plasma triacylglycerol (TAG) concentrations (P < 0.05). Animals fed starch diets exhibited a nascent VLDL containing less TAG/apo B and they also had faster VLDL apo B clearance than animals fed sucrose diets. In addition, VLDL removal from plasma with complex CHO:high fat intake was associated with less conversion of VLDL to LDL and decreased plasma cholesterol levels compared to the high fat: sucrose group Low fat intake compared to high fat intake resulted in 60% more rapid plasma LDL apo B fractional catabolic rates These results demonstrate that while low fat diets decrease plasma LDL cholesterol concentrations by increasing plasma LDL turnover rates, complex CHO reduce plasma TAG by affecting nascent VLDL composition and increasing VLDL apo B catabolism. [Studies supported by the American Heart Association, Arizona Affiliate],.
|Original language||English (US)|
|State||Published - 1996|
ASJC Scopus subject areas
- Molecular Biology