@article{712163ccff094a0b854d8a4393f0d8e1,
title = "Dietary carbohydrate intake, glycaemic load, glycaemic index and ovarian cancer risk in African-American women",
abstract = "Epidemiological evidence regarding the association between carbohydrate intake, glycaemic load (GL) and glycaemic index (GI) and risk of ovarian cancer has been mixed. Little is known about their impact on ovarian cancer risk in African-American women. Associations between carbohydrate quantity and quality and ovarian cancer risk were investigated among 406 cases and 609 controls using data from the African American Cancer Epidemiology Study (AACES). AACES is an ongoing population-based case-control study of ovarian cancer in African-Americans in the USA. Cases were identified through rapid case ascertainment and age- and site-matched controls were identified by random-digit dialling. Dietary information over the year preceding diagnosis or the reference date was obtained using a FFQ. Multivariable logistic regression models were used to estimate odds ratios and 95 % CI adjusted for covariates. The OR comparing the highest quartile of total carbohydrate intake and total sugar intake v. the lowest quartile were 1·57 (95 % CI 1·08, 2·28; P trend=0·03) and 1·61 (95 % CI 1·12, 2·30; P trend<0·01), respectively. A suggestion of an inverse association was found for fibre intake. Higher GL was positively associated with the risk of ovarian cancer (OR 1·18 for each 10 units/4184 kJ (1000 kcal); 95 % CI 1·04, 1·33). No associations were observed for starch or GI. Our findings suggest that high intake of total sugars and GL are associated with greater risk of ovarian cancer in African-American women.",
keywords = "African-American women, Carbohydrate, Epidemiology, Glycaemic load, Ovarian cancer",
author = "Bo Qin and Moorman, {Patricia G.} and Alberg, {Anthony J.} and Barnholtz-Sloan, {Jill S.} and Melissa Bondy and Cote, {Michele L.} and Ellen Funkhouser and Peters, {Edward S.} and Schwartz, {Ann G.} and Paul Terry and Schildkraut, {Joellen M.} and Bandera, {Elisa V.}",
note = "Funding Information: The authors acknowledge the AACES interviewers, Christine Bard, LaTonda Briggs, Whitney Franz (North Carolina) and Robin Gold (Detroit). The authors also acknowledge the individuals responsible for facilitating case ascertainment across the ten sites, including Jennifer Burczyk-Brown (Alabama); Rana Bayakly and Vicki Bennett (Georgia); the Louisiana Tumor Registry; Lisa Paddock and Manisha Narang (New Jersey); Diana Slone, Yingli Wolinsky, Steven Waggoner, Anne Heugel, Nancy Fusco, Kelly Ferguson, Peter Rose, Deb Strater, Taryn Ferber, Donna White, Lynn Borzi, Eric Jenison, Nairmeen Haller, Debbie Thomas, Vivian von Gruenigen, Michele McCarroll, Joyce Neading, John Geisler, Stephanie Smiddy, David Cohn, Michele Vaughan, Luis Vaccarello, Elayna Freese, James Pavelka, Pam Plummer, William Nahhas, Ellen Cato, John Moroney, Mark Wysong, Tonia Combs, Marci Bowling, Brandon Fletcher, Yingli Wolinsky (Ohio); Susan Bolick, Donna Acosta, Catherine Flanagan (South Carolina); Martin Whiteside (Tennessee) and Georgina Armstrong and the Texas Registry, Cancer Epidemiology and Surveillance Branch, Department of State Health Services. The AACES study was funded by NCI (R01CA142081). Additional support was provided by Metropolitan Detroit Cancer Surveillance System with federal funds from the National Cancer Institute, National Institute of Health, Department of Health and Human Services, under contract no. HHSN261201000028C and the Epidemiology Research Core, supported in part by NCI Center grant (P30CA22453) to the Karmanos Cancer Institute, Wayne State University School of Medicine and NCI Center grant (P30CA072720) to the Rutgers Cancer Institute of New Jersey. The funders had no role in the design, analysis or writing of this article. B. Q. and E. V. B.: study design and formulating the research question; P. G. M., A. J. A., J. S. B.-S., M. B., M. L. C., E. F., E. S. P., A. G. S., P. T., J. M. S. and E. V. B.: data acquisition; B. Q.: data analysis; B. Q. and E. V. B.: drafting the paper; B. Q.: primary responsibility for the final content; and all authors critically revised the paper and approved the final version of the manuscript. The authors declare that there are no conflicts of interest. Publisher Copyright: {\textcopyright} Copyright 2015 The Authors {\^A}.",
year = "2016",
month = feb,
day = "28",
doi = "10.1017/S0007114515004882",
language = "English (US)",
volume = "115",
pages = "694--702",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "4",
}