Dietary factors and risk of t(14;18)-defined subgroups of non-Hodgkin lymphoma

Brian C.H. Chiu, Bhavana J. Dave, Mary H. Ward, Angela J. Fought, Lifang Hou, Smrati Jain, Susan Gapstur, Andrew M. Evens, Shelia Hoar Zahm, Aaron Blair, Dennis D. Weisenburger

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Objective: To evaluate the associations between diet and non-Hodgkin lymphoma (NHL) according to t(14;18) status, one of the most common chromosomal abnormalities in NHL, as t(14;18)-positive NHL represents a genetically more homogeneous group than NHL overall. Methods: We determined the presence of the t(14;18)(q32;q21) by fluorescence in situ hybridization in 172 of 175 tumor blocks from a population-based, case-control study conducted in Nebraska during 1983-1986. Information on the frequency of consumption as an adult of 30 food items was derived from the parent case-control study. Dietary factors in 60 t(14;18)-positive and 87 t(14;18)-negative cases were compared with 1,075 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using polytomous logistic regression. Results: The risk of t(14;18)-positive NHL for the highest versus the lowest approximate tertile of intake was elevated for milk (OR = 2.2; 1.0-5.0) and dietary nitrite (OR = 2.8; 1.3-6.1), whereas coffee consumption was inversely associated with risk (OR = 0.4; 0.2-0.7). We also found inverse associations between the intake of fish (OR = 0.5; 0.3-1.0) and carotene (OR = 0.5; 0.2-0.9) and risk of t(14;18)-negative NHL. There was no association between the intake of meats, vegetables, protein, or vitamin C and risk of either t(14;18)-positive or t(14;18)-negative NHL. Conclusion: We observed differences in associations between diet and t(14;18)-defined subgroups of NHL. These findings should be interpreted cautiously because of the small sample.

Original languageEnglish (US)
Pages (from-to)859-867
Number of pages9
JournalCancer Causes and Control
Volume19
Issue number8
DOIs
StatePublished - Oct 2008

Keywords

  • Chromosomal aberrations
  • Diet
  • Epidemiology
  • Lymphoma
  • Non-Hodgkin
  • Risk factors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Chiu, B. C. H., Dave, B. J., Ward, M. H., Fought, A. J., Hou, L., Jain, S., Gapstur, S., Evens, A. M., Zahm, S. H., Blair, A., & Weisenburger, D. D. (2008). Dietary factors and risk of t(14;18)-defined subgroups of non-Hodgkin lymphoma. Cancer Causes and Control, 19(8), 859-867. https://doi.org/10.1007/s10552-008-9148-3