Cytochrome P-450 in rat liver nuclei was distinguishable from that in the corresponding liver microsomes. Characterization racterization was carried out using carbon monoxide and ethyl isocyanide binding difference spectra. Nuclear cytochrome P-450 in 3-methylcholanthrene-induced animals had different spectral properties from the nuclear cytochrome P-450 in uninduced and phenobarbital-induced animals. These spectral data demonstrate that hepatic nuclear cytochrome P-450 differs from the microsomal species.
|Original language||English (US)|
|Number of pages||5|
|State||Published - 1978|
ASJC Scopus subject areas
- Molecular Medicine