Abstract
Cytochrome P-450 in rat liver nuclei was distinguishable from that in the corresponding liver microsomes. Characterization racterization was carried out using carbon monoxide and ethyl isocyanide binding difference spectra. Nuclear cytochrome P-450 in 3-methylcholanthrene-induced animals had different spectral properties from the nuclear cytochrome P-450 in uninduced and phenobarbital-induced animals. These spectral data demonstrate that hepatic nuclear cytochrome P-450 differs from the microsomal species.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 215-219 |
| Number of pages | 5 |
| Journal | Molecular pharmacology |
| Volume | 14 |
| Issue number | 1 |
| State | Published - 1978 |
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology