Differences in regional brain volumes two months and one year after mild traumatic brain injury

Lyubomir Zagorchev, Carsten Meyer, Thomas Stehle, Fabian Wenzel, Stewart Young, Jochen Peters, Juergen Weese, Keith Paulsen, Matthew Garlinghouse, James Ford, Robert Roth, Laura Flashman, Thomas Mcallister

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Conventional structural imaging is often normal after mild traumatic brain injury (mTBI). There is a need for structural neuroimaging biomarkers that facilitate detection of milder injuries, allow recovery trajectory monitoring, and identify those at risk for poor functional outcome and disability. We present a novel approach to quantifying volumes of candidate brain regions at risk for injury. Compared to controls, patients with mTBI had significantly smaller volumes in several regions including the caudate, putamen, and thalamus when assessed 2 months after injury. These differences persisted but were reduced in magnitude 1 year after injury, suggesting the possibility of normalization over time in the affected regions. More pronounced differences, however, were found in the amygdala and hippocampus, suggesting the possibility of regionally specific responses to injury.

Original languageEnglish (US)
Pages (from-to)29-34
Number of pages6
JournalJournal of Neurotrauma
Issue number1
StatePublished - Jan 1 2016
Externally publishedYes


  • MRI
  • mild traumatic brain injury
  • subcortical structures
  • volume

ASJC Scopus subject areas

  • Clinical Neurology


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