Differences in the cytogenetic alteration profiles of diffuse large B-cell lymphoma among Chinese and American patients

Yan Chen, Bhavana J. Dave, Xiongzeng Zhu, Wing C. Chan, Javeed Iqbal, Warren G. Sanger, Kai Fu

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

To study the similarities and differences of cytogenetic alterations in diffuse large B-cell lymphoma (DLBCL) between Asian and Caucasian patients, we compared the cytogenetic profiles of Chinese and American DLBCL cases by analyzing conventional karyotypes and select fluorescence in situ hybridization (FISH) findings. We used interphase FISH analyses to determine the incidence of the t(14;18) and BCL6 and MYC rearrangements. Immunohistochemical analysis was used to categorize the lymphomas into the germinal center B-cell-like (GCB) or non-GCB-DLBCL subtypes, according to the Hans algorithm. Our data suggested that Chinese patients had cytogenetic profiles for GCB-DLBCL that differed from those of their American counterparts; specifically, the Chinese GCB patients exhibited greater frequencies of BCL6 rearrangements and gains of 1q and 11q but lower incidence of the t(14;18). Non-GCB-DLBCL in both the Chinese and American patients was characterized by recurrent gains of 3/3q and 18/18q. The incidences of both BCL6 rearrangement and t(14;18) were similar in Chinese and American non-GCB-DLBCL cases.

Original languageEnglish (US)
Pages (from-to)183-190
Number of pages8
JournalCancer Genetics
Volume206
Issue number5
DOIs
StatePublished - May 1 2013

Keywords

  • Activated B-cell-like DLBCL
  • Diffuse large B-cell lymphoma
  • Germinal center B-cell-like DLBCL
  • Hans algorithm
  • Immunohistochemistry

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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