Differences in the susceptibility of various aldose reductases to inhibition. II

P. F. Kador, J. H. Kinoshita, W. H. Tung, L. T. Chylack

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

The susceptibility of human lens aldose reductase (HLAR), human placental aldose reductase (HPAR), and rat lens aldose reductase (RLAR) to inhibition by 10 structurally diverse inhibitors is compared. Significant differences in the susceptibility of these enzymes was observed; however, no trends could be predicted. In general, HPAR appeared to be less susceptible to inhibition than either HLAR or RLAR, with the susceptibility of HLAR being more similar to RLAR than to HPAR. These findings indicate that the evaluation of aldose reductase inhibitors for potential clinical use may require the use of human aldose reductase from the appropriate target tissue.

Original languageEnglish (US)
Pages (from-to)980-982
Number of pages3
JournalInvestigative Ophthalmology and Visual Science
Volume19
Issue number8
StatePublished - 1980

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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