Differential characteristics of TP53 alterations in pure erythroid leukemia arising after exposure to cytotoxic therapy

Mehrnoosh Tashakori, Wei Wang, Tapan M. Kadia, Naval G. Daver, Guillermo Montalban-Bravo, Sanam Loghavi, Sa A. Wang, L. Jeffrey Medeiros, Farhad Ravandi, Joseph D. Khoury

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Pure erythroid leukemia (PEL) is a rare acute leukemia with a dismal prognosis. TP53 mutations are a dominant feature of PEL, but the characteristics of TP53 alterations in PEL without prior exposure to cytotoxic therapy (d-PEL) or with such exposure (t-PEL) is unknown. We studied 25 patients with TP53-mutated PEL including 16 d-PEL and 9 t-PEL. Both groups had comparable clinical findings and overall survival. The TP53 mutation, commonly missense, was present in the dominant clone in all cases. In the d-PEL group, 10/16 (62.5%) had one TP53 mutation compared to 8/9 (89%) patients in the t-PEL group. In the d-PEL group, 9/16 (56.2%) patients had hotspot mutations compared to 2 (22.2%) patients in the t-PEL group. Notably, monosomy 17 or del(17p) were less common in the d-PEL group (26.6%) compared to the t-PEL group (71.4%), underscoring distinctive TP53 alterations in d-PEL versus t-PEL, possibly reflecting different fitness advantages.

Original languageEnglish (US)
Article number106860
JournalLeukemia Research
Volume118
DOIs
StatePublished - Jul 2022
Externally publishedYes

Keywords

  • Copy number loss
  • Mutation
  • Pure erythroid leukemia
  • Selection pressure
  • TP53

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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