Differential regulation of cyclin D1 expression by protein kinase Cα and ∈ signaling in intestinal epithelial cells

Marybeth A. Pysz; Fang Hao; A. Asli Hizli; Michelle A. Lum; Wendy M. Swetzig; Adrian R. Black; Jennifer D. Black

doi:10.1074/jbc.M114.571554

Differential regulation of cyclin D1 expression by protein kinase Cα and ∈ signaling in intestinal epithelial cells

Marybeth A. Pysz, Fang Hao, A. Asli Hizli, Michelle A. Lum, Wendy M. Swetzig, Adrian R. Black, Jennifer D. Black

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Background: Tight control of cyclin D1 expression is critical for intestinal homeostasis. Results: Whereas PKCα suppresses cyclin D1 expression, PKC∈ up-regulates cyclin D1 via an ERK and NF-κB/CRE- mediated transcriptional mechanism. Conclusion: Cyclin D1 levels in intestinal cells reflect a balance between PKCα and PKC∈ signaling. Significance: The opposing effects of PKCα and PKC∈ on cyclin D1 accumulation reflect their contrasting contributions to intestinal tumorigenesis.

Original language	English (US)
Pages (from-to)	22268-22283
Number of pages	16
Journal	Journal of Biological Chemistry
Volume	289
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M114.571554
State	Published - Aug 8 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Differential regulation of cyclin D1 expression by protein kinase Cα and ∈ signaling in intestinal epithelial cells",

abstract = "Background: Tight control of cyclin D1 expression is critical for intestinal homeostasis. Results: Whereas PKCα suppresses cyclin D1 expression, PKC∈ up-regulates cyclin D1 via an ERK and NF-κB/CRE- mediated transcriptional mechanism. Conclusion: Cyclin D1 levels in intestinal cells reflect a balance between PKCα and PKC∈ signaling. Significance: The opposing effects of PKCα and PKC∈ on cyclin D1 accumulation reflect their contrasting contributions to intestinal tumorigenesis.",

author = "Pysz, {Marybeth A.} and Fang Hao and Hizli, {A. Asli} and Lum, {Michelle A.} and Swetzig, {Wendy M.} and Black, {Adrian R.} and Black, {Jennifer D.}",

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doi = "10.1074/jbc.M114.571554",

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AU - Pysz, Marybeth A.

AU - Hao, Fang

AU - Hizli, A. Asli

AU - Lum, Michelle A.

AU - Swetzig, Wendy M.

AU - Black, Adrian R.

AU - Black, Jennifer D.

PY - 2014/8/8

Y1 - 2014/8/8

N2 - Background: Tight control of cyclin D1 expression is critical for intestinal homeostasis. Results: Whereas PKCα suppresses cyclin D1 expression, PKC∈ up-regulates cyclin D1 via an ERK and NF-κB/CRE- mediated transcriptional mechanism. Conclusion: Cyclin D1 levels in intestinal cells reflect a balance between PKCα and PKC∈ signaling. Significance: The opposing effects of PKCα and PKC∈ on cyclin D1 accumulation reflect their contrasting contributions to intestinal tumorigenesis.

AB - Background: Tight control of cyclin D1 expression is critical for intestinal homeostasis. Results: Whereas PKCα suppresses cyclin D1 expression, PKC∈ up-regulates cyclin D1 via an ERK and NF-κB/CRE- mediated transcriptional mechanism. Conclusion: Cyclin D1 levels in intestinal cells reflect a balance between PKCα and PKC∈ signaling. Significance: The opposing effects of PKCα and PKC∈ on cyclin D1 accumulation reflect their contrasting contributions to intestinal tumorigenesis.

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Differential regulation of cyclin D1 expression by protein kinase Cα and ∈ signaling in intestinal epithelial cells

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