Differential regulation of cyclin D1 expression by protein kinase Cα and ∈ signaling in intestinal epithelial cells

Marybeth A. Pysz, Fang Hao, A. Asli Hizli, Michelle A. Lum, Wendy M. Swetzig, Adrian R. Black, Jennifer D. Black

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background: Tight control of cyclin D1 expression is critical for intestinal homeostasis. Results: Whereas PKCα suppresses cyclin D1 expression, PKC∈ up-regulates cyclin D1 via an ERK and NF-κB/CRE- mediated transcriptional mechanism. Conclusion: Cyclin D1 levels in intestinal cells reflect a balance between PKCα and PKC∈ signaling. Significance: The opposing effects of PKCα and PKC∈ on cyclin D1 accumulation reflect their contrasting contributions to intestinal tumorigenesis.

Original languageEnglish (US)
Pages (from-to)22268-22283
Number of pages16
JournalJournal of Biological Chemistry
Volume289
Issue number32
DOIs
StatePublished - Aug 8 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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