Differential regulation of myometrial prostaglandin production by changes in length

William W. Hurd, Shawn G. Gibbs, Kari A. Rudinsky

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Objective: The purpose of this study was to determine whether stretching and shortening of human myometrial strips alters prostaglandin production. Study Design: We measured 6-keto prostaglandin F (PGF; a PGI2 metabolite) and PGF in the contraction baths of myometrial strips that were obtained at cesarean delivery from 5 term pregnant women. Fluid was collected after the stretching and after the strip lengths were decreased by 4%, 6%, or 8%. Prostaglandin concentrations were measured in triplicate by competitive enzyme immunoassay and compared by Kruskal-Wallis tests. Results: Stretching myometrial strips increased the production of 6-keto PGF by 31%, but not PGF. Shortening strips had little effect on 6-keto PGF production, but increased PGF production by 158%. Conclusion: Stretching myometrial strips from pregnant women increases synthesis of PGI2; shortening strips increases synthesis of PGF. Differential prostaglandin synthesis that is related to myometrial stretching and shortening could play a role in uterine quiescence during gestation and increased contractility during parturition.

Original languageEnglish (US)
Pages (from-to)225.e1-225.e4
JournalAmerican Journal of Obstetrics and Gynecology
Volume198
Issue number2
DOIs
StatePublished - Feb 2008

Keywords

  • mechanotransduction
  • myometrium
  • parturition
  • pregnancy
  • prostaglandin

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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