Differential roles of C-terminal eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes

Bishuang Cai, Sai Srinivas Panapakkam Giridharan, Jing Zhang, Sugandha Saxena, Kriti Bahl, John A. Schmidt, Paul L. Sorgen, Wei Guo, Naava Naslavsky, Steve Caplan

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Background: Vesiculation of tubular recycling endosomes is essential for the recycling of receptors and lipids to the plasma membrane. Results: A novel vesiculation assay was used to demonstrate a role for endocytic regulatory proteins in vesiculation. Conclusion: EHD family proteins play significant roles in both the vesiculation and generation of tubular recycling endosomes. Significance: This provides the first direct evidence of differential EHD function in vesiculation and tubulation.

Original languageEnglish (US)
Pages (from-to)30172-30180
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number42
DOIs
StatePublished - Oct 18 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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