Differential roles of C-terminal eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes

Bishuang Cai; Sai Srinivas Panapakkam Giridharan; Jing Zhang; Sugandha Saxena; Kriti Bahl; John A. Schmidt; Paul L. Sorgen; Wei Guo; Naava Naslavsky; Steve Caplan

doi:10.1074/jbc.M113.488627

Differential roles of C-terminal eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes

Bishuang Cai, Sai Srinivas Panapakkam Giridharan, Jing Zhang, Sugandha Saxena, Kriti Bahl, John A. Schmidt, Paul L. Sorgen, Wei Guo, Naava Naslavsky, Steve Caplan

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Background: Vesiculation of tubular recycling endosomes is essential for the recycling of receptors and lipids to the plasma membrane. Results: A novel vesiculation assay was used to demonstrate a role for endocytic regulatory proteins in vesiculation. Conclusion: EHD family proteins play significant roles in both the vesiculation and generation of tubular recycling endosomes. Significance: This provides the first direct evidence of differential EHD function in vesiculation and tubulation.

Original language	English (US)
Pages (from-to)	30172-30180
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	288
Issue number	42
DOIs	https://doi.org/10.1074/jbc.M113.488627
State	Published - Oct 18 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1074/jbc.M113.488627

Cite this

@article{947b09a8c43a44d7979abe99bce37e1a,

title = "Differential roles of C-terminal eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes",

abstract = "Background: Vesiculation of tubular recycling endosomes is essential for the recycling of receptors and lipids to the plasma membrane. Results: A novel vesiculation assay was used to demonstrate a role for endocytic regulatory proteins in vesiculation. Conclusion: EHD family proteins play significant roles in both the vesiculation and generation of tubular recycling endosomes. Significance: This provides the first direct evidence of differential EHD function in vesiculation and tubulation.",

author = "Bishuang Cai and Giridharan, {Sai Srinivas Panapakkam} and Jing Zhang and Sugandha Saxena and Kriti Bahl and Schmidt, {John A.} and Sorgen, {Paul L.} and Wei Guo and Naava Naslavsky and Steve Caplan",

year = "2013",

month = oct,

day = "18",

doi = "10.1074/jbc.M113.488627",

language = "English (US)",

volume = "288",

pages = "30172--30180",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "42",

}

TY - JOUR

T1 - Differential roles of C-terminal eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes

AU - Cai, Bishuang

AU - Giridharan, Sai Srinivas Panapakkam

AU - Zhang, Jing

AU - Saxena, Sugandha

AU - Bahl, Kriti

AU - Schmidt, John A.

AU - Sorgen, Paul L.

AU - Guo, Wei

AU - Naslavsky, Naava

AU - Caplan, Steve

PY - 2013/10/18

Y1 - 2013/10/18

N2 - Background: Vesiculation of tubular recycling endosomes is essential for the recycling of receptors and lipids to the plasma membrane. Results: A novel vesiculation assay was used to demonstrate a role for endocytic regulatory proteins in vesiculation. Conclusion: EHD family proteins play significant roles in both the vesiculation and generation of tubular recycling endosomes. Significance: This provides the first direct evidence of differential EHD function in vesiculation and tubulation.

AB - Background: Vesiculation of tubular recycling endosomes is essential for the recycling of receptors and lipids to the plasma membrane. Results: A novel vesiculation assay was used to demonstrate a role for endocytic regulatory proteins in vesiculation. Conclusion: EHD family proteins play significant roles in both the vesiculation and generation of tubular recycling endosomes. Significance: This provides the first direct evidence of differential EHD function in vesiculation and tubulation.

UR - http://www.scopus.com/inward/record.url?scp=84886888066&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886888066&partnerID=8YFLogxK

U2 - 10.1074/jbc.M113.488627

DO - 10.1074/jbc.M113.488627

M3 - Article

C2 - 24019528

AN - SCOPUS:84886888066

SN - 0021-9258

VL - 288

SP - 30172

EP - 30180

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 42

ER -

Differential roles of C-terminal eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this