Dilazep-induced vasodilation is mediated through adenosine receptors

Yong Zhang; Jonathan D. Geiger; Dallas J. Légaré; W. Wayne Lautt

doi:10.1016/0024-3205(91)90202-M

Dilazep-induced vasodilation is mediated through adenosine receptors

Yong Zhang, Jonathan D. Geiger, Dallas J. Légaré, W. Wayne Lautt

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Administration of dilazep, an inhibitor of adenosine uptake, significantly reduced systemic arterial blood pressure and increased superior mesenteric arterial conductance without affecting the plasma adenosine levels of femoral arterial or portal venous blood. Administration of a bolus dose of 8-phenyltheophylline (8-PT), an antagonist of adenosine receptors, blocked adenosine-mediated autoregulation of the superior mesenteric artery. After the blockade of adenosine receptors by 8-PT, dilazep did not produce vasodilation. These data suggest that dilazep has a vasodilating effect in vivo that is mediated by adenosine.

Original language	English (US)
Pages (from-to)	PL129-PL133
Journal	Life Sciences
Volume	49
Issue number	18
DOIs	https://doi.org/10.1016/0024-3205(91)90202-M
State	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(91)90202-M

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title = "Dilazep-induced vasodilation is mediated through adenosine receptors",

abstract = "Administration of dilazep, an inhibitor of adenosine uptake, significantly reduced systemic arterial blood pressure and increased superior mesenteric arterial conductance without affecting the plasma adenosine levels of femoral arterial or portal venous blood. Administration of a bolus dose of 8-phenyltheophylline (8-PT), an antagonist of adenosine receptors, blocked adenosine-mediated autoregulation of the superior mesenteric artery. After the blockade of adenosine receptors by 8-PT, dilazep did not produce vasodilation. These data suggest that dilazep has a vasodilating effect in vivo that is mediated by adenosine.",

author = "Yong Zhang and Geiger, {Jonathan D.} and L{\'e}gar{\'e}, {Dallas J.} and {Wayne Lautt}, W.",

note = "Funding Information: We are grateful for the superb technical assistance of Melanie Johnson. We would also like to thank Karen Sanders for manuscript preparation. This project was supported by operating grants from the Medical Research Council of Canada (MRC), the Manitoba Heart and Stroke Foundation, and the Health Sciences Center Research Foundation. YZ is a Postdoctoral Fellow of the University of Manitoba. JDG is a Scholar of the MRC.",

year = "1991",

doi = "10.1016/0024-3205(91)90202-M",

language = "English (US)",

volume = "49",

pages = "PL129--PL133",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "18",

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TY - JOUR

T1 - Dilazep-induced vasodilation is mediated through adenosine receptors

AU - Zhang, Yong

AU - Geiger, Jonathan D.

AU - Légaré, Dallas J.

AU - Wayne Lautt, W.

N1 - Funding Information: We are grateful for the superb technical assistance of Melanie Johnson. We would also like to thank Karen Sanders for manuscript preparation. This project was supported by operating grants from the Medical Research Council of Canada (MRC), the Manitoba Heart and Stroke Foundation, and the Health Sciences Center Research Foundation. YZ is a Postdoctoral Fellow of the University of Manitoba. JDG is a Scholar of the MRC.

PY - 1991

Y1 - 1991

N2 - Administration of dilazep, an inhibitor of adenosine uptake, significantly reduced systemic arterial blood pressure and increased superior mesenteric arterial conductance without affecting the plasma adenosine levels of femoral arterial or portal venous blood. Administration of a bolus dose of 8-phenyltheophylline (8-PT), an antagonist of adenosine receptors, blocked adenosine-mediated autoregulation of the superior mesenteric artery. After the blockade of adenosine receptors by 8-PT, dilazep did not produce vasodilation. These data suggest that dilazep has a vasodilating effect in vivo that is mediated by adenosine.

AB - Administration of dilazep, an inhibitor of adenosine uptake, significantly reduced systemic arterial blood pressure and increased superior mesenteric arterial conductance without affecting the plasma adenosine levels of femoral arterial or portal venous blood. Administration of a bolus dose of 8-phenyltheophylline (8-PT), an antagonist of adenosine receptors, blocked adenosine-mediated autoregulation of the superior mesenteric artery. After the blockade of adenosine receptors by 8-PT, dilazep did not produce vasodilation. These data suggest that dilazep has a vasodilating effect in vivo that is mediated by adenosine.

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ER -

Dilazep-induced vasodilation is mediated through adenosine receptors

Abstract

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