Direct comparison of theoretical and experimental melting profiles for RFII ΦX174 DNA

Y. L. Lyubchenko, A. V. Vologodskii, M. D. Frank-Kamenetskii

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

The determination by Sanger et al. of the complete nucleotide sequence for ΦX174 DNA has made it possible for the first time to compare directly theoretical and experimental DNA melting profiles. The comparison shows that the theory predicts the observed shape of the differential melting curve surprisingly well. Calculation of the denaturation maps allows the peaks on the curve to be correlated with cooperative melting out of concrete regions on the sequence of nucleotides.

Original languageEnglish (US)
Pages (from-to)28-31
Number of pages4
JournalNature
Volume271
Issue number5640
DOIs
StatePublished - 1978

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Direct comparison of theoretical and experimental melting profiles for RFII ΦX174 DNA'. Together they form a unique fingerprint.

  • Cite this