Direct comparison of theoretical and experimental melting profiles for RFII ΦX174 DNA

Y. L. Lyubchenko; A. V. Vologodskii; M. D. Frank-Kamenetskii

doi:10.1038/271028a0

Direct comparison of theoretical and experimental melting profiles for RFII ΦX174 DNA

Y. L. Lyubchenko, A. V. Vologodskii, M. D. Frank-Kamenetskii

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Abstract

The determination by Sanger et al. of the complete nucleotide sequence for ΦX174 DNA has made it possible for the first time to compare directly theoretical and experimental DNA melting profiles. The comparison shows that the theory predicts the observed shape of the differential melting curve surprisingly well. Calculation of the denaturation maps allows the peaks on the curve to be correlated with cooperative melting out of concrete regions on the sequence of nucleotides.

Original language	English (US)
Pages (from-to)	28-31
Number of pages	4
Journal	Nature
Volume	271
Issue number	5640
DOIs	https://doi.org/10.1038/271028a0
State	Published - 1978
Externally published	Yes

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title = "Direct comparison of theoretical and experimental melting profiles for RFII ΦX174 DNA",

abstract = "The determination by Sanger et al. of the complete nucleotide sequence for ΦX174 DNA has made it possible for the first time to compare directly theoretical and experimental DNA melting profiles. The comparison shows that the theory predicts the observed shape of the differential melting curve surprisingly well. Calculation of the denaturation maps allows the peaks on the curve to be correlated with cooperative melting out of concrete regions on the sequence of nucleotides.",

author = "Lyubchenko, {Y. L.} and Vologodskii, {A. V.} and Frank-Kamenetskii, {M. D.}",

year = "1978",

doi = "10.1038/271028a0",

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journal = "Nature",

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T1 - Direct comparison of theoretical and experimental melting profiles for RFII ΦX174 DNA

AU - Lyubchenko, Y. L.

AU - Vologodskii, A. V.

AU - Frank-Kamenetskii, M. D.

PY - 1978

Y1 - 1978

N2 - The determination by Sanger et al. of the complete nucleotide sequence for ΦX174 DNA has made it possible for the first time to compare directly theoretical and experimental DNA melting profiles. The comparison shows that the theory predicts the observed shape of the differential melting curve surprisingly well. Calculation of the denaturation maps allows the peaks on the curve to be correlated with cooperative melting out of concrete regions on the sequence of nucleotides.

AB - The determination by Sanger et al. of the complete nucleotide sequence for ΦX174 DNA has made it possible for the first time to compare directly theoretical and experimental DNA melting profiles. The comparison shows that the theory predicts the observed shape of the differential melting curve surprisingly well. Calculation of the denaturation maps allows the peaks on the curve to be correlated with cooperative melting out of concrete regions on the sequence of nucleotides.

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Direct comparison of theoretical and experimental melting profiles for RFII ΦX174 DNA

Abstract

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