Direct evidence for myogenic autoregulation of the renal microcirculation in the hamster

J. P. Gilmore, K. G. Cornish, S. D. Rogers, W. L. Joyner

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

We transplanted neonatal hamster renal tissue into a hamster cheek pouch chamber and subjected the renal tissue to increases and decreases in extravascular pressure. A decrease in extravascular pressure decreased, and an increase in extravascular pressure increased, the diameter of preglomerular arterioles. Thus, the change in preglomerular arteriolar diameter was directly related to alterations in extravascular pressure. Neither saralasin nor indomethacin affected these changes, whereas papaverin prevented them. The efferent arterioles responded passively to changes in extravascular pressure; i.e., the changes in their diameter were inversely related to changes in extravascular myogenic autoregulation of preglomerular vessels.

Original languageEnglish (US)
Pages (from-to)226-230
Number of pages5
JournalCirculation Research
Volume47
Issue number2
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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