Direct in vivo evaluation of pulmonary arterial pathology in chronic congestive heart failure with catheter-based intravascular ultrasound imaging

Thomas R. Porter; David O. Taylor; Jennifer Fields; Alan Cycan; Kwame Akosah; Pramod K. Mohanty; Natesa G. Pandian

doi:10.1016/0002-9149(93)91024-C

Direct in vivo evaluation of pulmonary arterial pathology in chronic congestive heart failure with catheter-based intravascular ultrasound imaging

Thomas R. Porter, David O. Taylor, Jennifer Fields, Alan Cycan, Kwame Akosah, Pramod K. Mohanty, Natesa G. Pandian

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Patients with chronic congestive heart failure (CHF) frequently develop secondary pulmonary hypertension. This development is a poor prognostic indicator.¹ In addition, secondary pulmonary hypertension that does not improve in response to vasodilators identifies a group of patients who will have a poor outcome after orthotopic heart transplantation.^2,3 The structural abnormalities of the pulmonary artery that occur in CHF have been described in autopsy specimens,⁴ and human studies have demonstrated indirectly that there are alterations in pulmonary vascular impedance and stiffness.^5,6 Intravascular ultrasound using high-frequency catheter-based imaging has been performed to quantify pulmonary artery area and diameter in humans.⁷ It also has been validated as a method of detecting plaque in both elastic and muscular arteries.⁸ We hypothesized that intravascular ultrasound could be used to characterize the changes in pulmonary vascular morphology and elasticity in CHF.

Original language	English (US)
Pages (from-to)	754-757
Number of pages	4
Journal	The American Journal of Cardiology
Volume	71
Issue number	8
DOIs	https://doi.org/10.1016/0002-9149(93)91024-C
State	Published - Mar 15 1993
Externally published	Yes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/0002-9149(93)91024-C

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@article{873a5d2cf8204137a63dce8f05501493,

title = "Direct in vivo evaluation of pulmonary arterial pathology in chronic congestive heart failure with catheter-based intravascular ultrasound imaging",

abstract = "Patients with chronic congestive heart failure (CHF) frequently develop secondary pulmonary hypertension. This development is a poor prognostic indicator.1 In addition, secondary pulmonary hypertension that does not improve in response to vasodilators identifies a group of patients who will have a poor outcome after orthotopic heart transplantation.2,3 The structural abnormalities of the pulmonary artery that occur in CHF have been described in autopsy specimens,4 and human studies have demonstrated indirectly that there are alterations in pulmonary vascular impedance and stiffness.5,6 Intravascular ultrasound using high-frequency catheter-based imaging has been performed to quantify pulmonary artery area and diameter in humans.7 It also has been validated as a method of detecting plaque in both elastic and muscular arteries.8 We hypothesized that intravascular ultrasound could be used to characterize the changes in pulmonary vascular morphology and elasticity in CHF.",

author = "Porter, {Thomas R.} and Taylor, {David O.} and Jennifer Fields and Alan Cycan and Kwame Akosah and Mohanty, {Pramod K.} and Pandian, {Natesa G.}",

note = "Funding Information: From the McGuire Veterans Affairs Medical Center, Medical College of Virginia/Virginia Commonwealth University, Richmond, Virginia; and Tufts University School of Medicine, Boston, Massachusetts. This study was supported by the McGuire Veterans Affairs Research Service, Richmond, Virginia. Dr. Porter{\textquoteright}s current address is: University of Nebraska Medical Center, 600 South 42 Street, Omaha, Nebraska 68198-2265. Manuscript received May 19, 1992; revised manuscript received September 18, 1992, and accepted September 19.",

year = "1993",

month = mar,

day = "15",

doi = "10.1016/0002-9149(93)91024-C",

language = "English (US)",

volume = "71",

pages = "754--757",

journal = "The American Journal of Cardiology",

issn = "0002-9149",

publisher = "Elsevier Inc.",

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T1 - Direct in vivo evaluation of pulmonary arterial pathology in chronic congestive heart failure with catheter-based intravascular ultrasound imaging

AU - Porter, Thomas R.

AU - Taylor, David O.

AU - Fields, Jennifer

AU - Cycan, Alan

AU - Akosah, Kwame

AU - Mohanty, Pramod K.

AU - Pandian, Natesa G.

N1 - Funding Information: From the McGuire Veterans Affairs Medical Center, Medical College of Virginia/Virginia Commonwealth University, Richmond, Virginia; and Tufts University School of Medicine, Boston, Massachusetts. This study was supported by the McGuire Veterans Affairs Research Service, Richmond, Virginia. Dr. Porter’s current address is: University of Nebraska Medical Center, 600 South 42 Street, Omaha, Nebraska 68198-2265. Manuscript received May 19, 1992; revised manuscript received September 18, 1992, and accepted September 19.

PY - 1993/3/15

Y1 - 1993/3/15

N2 - Patients with chronic congestive heart failure (CHF) frequently develop secondary pulmonary hypertension. This development is a poor prognostic indicator.1 In addition, secondary pulmonary hypertension that does not improve in response to vasodilators identifies a group of patients who will have a poor outcome after orthotopic heart transplantation.2,3 The structural abnormalities of the pulmonary artery that occur in CHF have been described in autopsy specimens,4 and human studies have demonstrated indirectly that there are alterations in pulmonary vascular impedance and stiffness.5,6 Intravascular ultrasound using high-frequency catheter-based imaging has been performed to quantify pulmonary artery area and diameter in humans.7 It also has been validated as a method of detecting plaque in both elastic and muscular arteries.8 We hypothesized that intravascular ultrasound could be used to characterize the changes in pulmonary vascular morphology and elasticity in CHF.

AB - Patients with chronic congestive heart failure (CHF) frequently develop secondary pulmonary hypertension. This development is a poor prognostic indicator.1 In addition, secondary pulmonary hypertension that does not improve in response to vasodilators identifies a group of patients who will have a poor outcome after orthotopic heart transplantation.2,3 The structural abnormalities of the pulmonary artery that occur in CHF have been described in autopsy specimens,4 and human studies have demonstrated indirectly that there are alterations in pulmonary vascular impedance and stiffness.5,6 Intravascular ultrasound using high-frequency catheter-based imaging has been performed to quantify pulmonary artery area and diameter in humans.7 It also has been validated as a method of detecting plaque in both elastic and muscular arteries.8 We hypothesized that intravascular ultrasound could be used to characterize the changes in pulmonary vascular morphology and elasticity in CHF.

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Direct in vivo evaluation of pulmonary arterial pathology in chronic congestive heart failure with catheter-based intravascular ultrasound imaging

Abstract

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