TY - JOUR
T1 - Direct numerical simulation of a pulsatile flow in a stenotic channel using immersed boundary method
AU - Mirfendereski, Siamak
AU - Park, Jae Sung
N1 - Funding Information:
information National Science Foundation, CBET-1936065; University of Nebraska, Collaboration InitiativeThe authors gratefully acknowledge financial support from the Collaboration Initiative at the University of Nebraska and, in part, from the National Science Foundation through Grant No. CBET-1936065 (Particulate and Multiphase Processes program). The authors would also like to thank S. Ryu & T. Wei at the University of Nebraska-Lincoln and X. Liu & Y. Chatzizisis at the University of Nebraska Medical Center for fruitful discussions. This work was completed utilizing the Holland Computing Center of the University of Nebraska, which receives support from the Nebraska Research Initiative.
Publisher Copyright:
© 2021 The Authors. Engineering Reports published by John Wiley & Sons Ltd.
PY - 2022/1
Y1 - 2022/1
N2 - A three-dimensional direct numerical simulation model coupled with the immersed boundary method has been developed to simulate a pulsatile flow in a planar channel with single and double one-sided semicircular constrictions. For relevance to blood flow in large arteries, simulations have been performed at Reynolds numbers of 750 and 1000. Flow physics and resultant wall shear stress (WSS)-based hemodynamic parameters are presented. The instantaneous vortex dynamics, mean flow characteristics, and turbulent energy spectra are evaluated for flow physics. Subsequently, three WSS-based parameters, namely the time-averaged WSS, oscillatory shear index, and relative residence time, are calculated over the stenotic wall and correlated with flow physics to identify the regions prone to atherosclerotic plaque progression. Results show that the double stenotic channel leads to high-intensity and broadband turbulent characteristics downstream, promoting critical values of the WSS-based parameters in the post-stenotic areas. In addition, the inter-space area between two stenoses displays multiple strong recirculations, making this area highly prone to atherosclerosis progression. The effect of stenosis degree on the WSS-based parameters is studied up to 60% degree. As the degree of occlusion is increased, larger regions are involved with the nonphysiological ranges of the WSS-based parameters.
AB - A three-dimensional direct numerical simulation model coupled with the immersed boundary method has been developed to simulate a pulsatile flow in a planar channel with single and double one-sided semicircular constrictions. For relevance to blood flow in large arteries, simulations have been performed at Reynolds numbers of 750 and 1000. Flow physics and resultant wall shear stress (WSS)-based hemodynamic parameters are presented. The instantaneous vortex dynamics, mean flow characteristics, and turbulent energy spectra are evaluated for flow physics. Subsequently, three WSS-based parameters, namely the time-averaged WSS, oscillatory shear index, and relative residence time, are calculated over the stenotic wall and correlated with flow physics to identify the regions prone to atherosclerotic plaque progression. Results show that the double stenotic channel leads to high-intensity and broadband turbulent characteristics downstream, promoting critical values of the WSS-based parameters in the post-stenotic areas. In addition, the inter-space area between two stenoses displays multiple strong recirculations, making this area highly prone to atherosclerosis progression. The effect of stenosis degree on the WSS-based parameters is studied up to 60% degree. As the degree of occlusion is increased, larger regions are involved with the nonphysiological ranges of the WSS-based parameters.
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U2 - 10.1002/eng2.12444
DO - 10.1002/eng2.12444
M3 - Article
AN - SCOPUS:85122946588
VL - 4
JO - Engineering Reports
JF - Engineering Reports
SN - 2577-8196
IS - 1
M1 - e12444
ER -