Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells

Craig T. Morita, Evan M. Beckman, Jack F. Bukowski, Yoshimasa Tanaka, Hamid Band, Barry R. Bloom, David E. Golan, Michael B. Brenner

Research output: Contribution to journalArticle

403 Scopus citations

Abstract

Human Vγ2Vδ2+ T cells recognize mycobacterial non-peptide antigens, such as isopentenyl pyrophosphate, and their synthetic analogs, such as monoethyl phosphate, through a TCR-dependent process. Here, we examine the presentation of these antigens. Vγ2Vδ2+ T cells recognized secreted prenyl pyrophosphate antigens in the absence of other accessory cells but, under such conditions, required T cell-T cell contact. Recognition required neither the expression of classical MHC class I, MHC class II, or CD1a, CD1b, and CD1c molecules, nor MHC class I or class II peptide loading pathways. Fixed accessory cells also presented the prenyl pyrophosphate antigens to γδ T cells. Thus, in contrast with the presentation of conventional peptide antigens, protein antigens, and superantigens to αβ T cells, prenyl pyrophosphate antigens are presented to γδ T cells through a novel extracellular pathway that does not require antigen uptake, antigen processing, or MHC class I or class II expression. This pathway allows for the rapid recognition of bacteria by γδ T cells and suggests that γδ T cells play a role in the early response to bacterial infection.

Original languageEnglish (US)
Pages (from-to)495-507
Number of pages13
JournalImmunity
Volume3
Issue number4
DOIs
StatePublished - Oct 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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    Morita, C. T., Beckman, E. M., Bukowski, J. F., Tanaka, Y., Band, H., Bloom, B. R., Golan, D. E., & Brenner, M. B. (1995). Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells. Immunity, 3(4), 495-507. https://doi.org/10.1016/1074-7613(95)90178-7