Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation

Kathleen M. Healey; Steven Z. Pavletic; Jinan Al-Omaishi; M. Patricia Leuschen; Samuel J. Pirruccello; Mary L. Filipi; Charles Enke; Mary Margaret Ursick; Francis Hahn; J. D. Bowen; Richard A. Nash

doi:10.1191/1352458504ms1022oa

Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation

Kathleen M. Healey, Steven Z. Pavletic, Jinan Al-Omaishi, M. Patricia Leuschen, Samuel J. Pirruccello, Mary L. Filipi, Charles Enke, Mary Margaret Ursick, Francis Hahn, J. D. Bowen, Richard A. Nash

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

This article describes outcomes in four patients with advanced multiple sclerosis up to two years after autologous haematopoietic stem cell transplantation using a total-body irradiation-based preparative regimen. MRI and CSF analyses demonstrated clear suppression of the inflammatory processes. The results demonstrate however, a dissociation of inflammation parameters and functional disability findings raising questions about optimal future stem cell transplantation strategies for this disease.

Original language	English (US)
Pages (from-to)	284-289
Number of pages	6
Journal	Multiple Sclerosis
Volume	10
Issue number	3
DOIs	https://doi.org/10.1191/1352458504ms1022oa
State	Published - Jun 2004

Keywords

Autologous stem cell transplantation
Functional outcomes
Multiple sclerosis

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1191/1352458504ms1022oa

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Healey, K. M., Pavletic, S. Z., Al-Omaishi, J., Leuschen, M. P., Pirruccello, S. J., Filipi, M. L., Enke, C., Ursick, M. M., Hahn, F., Bowen, J. D., & Nash, R. A. (2004). Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation. Multiple Sclerosis, 10(3), 284-289. https://doi.org/10.1191/1352458504ms1022oa

Healey, KM, Pavletic, SZ, Al-Omaishi, J, Leuschen, MP, Pirruccello, SJ, Filipi, ML, Enke, C, Ursick, MM, Hahn, F, Bowen, JD & Nash, RA 2004, 'Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation', Multiple Sclerosis, vol. 10, no. 3, pp. 284-289. https://doi.org/10.1191/1352458504ms1022oa

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abstract = "This article describes outcomes in four patients with advanced multiple sclerosis up to two years after autologous haematopoietic stem cell transplantation using a total-body irradiation-based preparative regimen. MRI and CSF analyses demonstrated clear suppression of the inflammatory processes. The results demonstrate however, a dissociation of inflammation parameters and functional disability findings raising questions about optimal future stem cell transplantation strategies for this disease.",

keywords = "Autologous stem cell transplantation, Functional outcomes, Multiple sclerosis",

author = "Healey, {Kathleen M.} and Pavletic, {Steven Z.} and Jinan Al-Omaishi and Leuschen, {M. Patricia} and Pirruccello, {Samuel J.} and Filipi, {Mary L.} and Charles Enke and Ursick, {Mary Margaret} and Francis Hahn and Bowen, {J. D.} and Nash, {Richard A.}",

year = "2004",

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AU - Al-Omaishi, Jinan

AU - Leuschen, M. Patricia

AU - Pirruccello, Samuel J.

AU - Filipi, Mary L.

AU - Enke, Charles

AU - Ursick, Mary Margaret

AU - Hahn, Francis

AU - Bowen, J. D.

AU - Nash, Richard A.

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N2 - This article describes outcomes in four patients with advanced multiple sclerosis up to two years after autologous haematopoietic stem cell transplantation using a total-body irradiation-based preparative regimen. MRI and CSF analyses demonstrated clear suppression of the inflammatory processes. The results demonstrate however, a dissociation of inflammation parameters and functional disability findings raising questions about optimal future stem cell transplantation strategies for this disease.

AB - This article describes outcomes in four patients with advanced multiple sclerosis up to two years after autologous haematopoietic stem cell transplantation using a total-body irradiation-based preparative regimen. MRI and CSF analyses demonstrated clear suppression of the inflammatory processes. The results demonstrate however, a dissociation of inflammation parameters and functional disability findings raising questions about optimal future stem cell transplantation strategies for this disease.

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Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation

Abstract

Keywords

ASJC Scopus subject areas

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