Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation

Kathleen M. Healey, Steven Z. Pavletic, Jinan Al-Omaishi, M. Patricia Leuschen, Samuel J. Pirruccello, Mary L. Filipi, Charles Enke, Mary Margaret Ursick, Francis Hahn, J. D. Bowen, Richard A. Nash

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

This article describes outcomes in four patients with advanced multiple sclerosis up to two years after autologous haematopoietic stem cell transplantation using a total-body irradiation-based preparative regimen. MRI and CSF analyses demonstrated clear suppression of the inflammatory processes. The results demonstrate however, a dissociation of inflammation parameters and functional disability findings raising questions about optimal future stem cell transplantation strategies for this disease.

Original languageEnglish (US)
Pages (from-to)284-289
Number of pages6
JournalMultiple Sclerosis
Volume10
Issue number3
DOIs
StatePublished - Jun 2004

Keywords

  • Autologous stem cell transplantation
  • Functional outcomes
  • Multiple sclerosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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