Discovering the route from inflammation to pancreatic cancer

N. Momi, S. Kaur, S. R. Krishn, S. K. Batra

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

Pancreatic cancer (PC) remains a complex malignancy with the worst prognosis, lack of early diagnostic symptoms and resistance to conventional chemo- and radiotherapies. A better understanding of the etiology and early developmental events of PC requires profound attention. The evolution of fully blown PC from initial pancreatic injury is a multi-factorial phenomenon with a series of sequential events. The initial acute infection or tissue damage triggers inflammation that, in conjunction with innate immunity, establishes a state of homeostasis to limit harm to the body. Recurrent pancreatic injuries due to genetic susceptibility, smoking, unhealthy diet, and alcohol abuse induces a pro-inflammatory milieu, consisting of various types of immune cells, cytokines, chemokines, growth factors and restructured extracellular matrix, leading to prolonged inflammatory/chronic conditions. Cells having sustained DNA damage and/or mutagenic assault take advantage of this prolonged inflammatory response and aid in the initiation and development of neoplastic/fibrotic events. Eventually, many tumor-stromal interactions result in a chaotic environment accompanied by a loss of immune surveillance and repair response, thereby leading to PC. A better understanding of the inflammatory markers defining this "injury-inflammation-cancer" pathway would help to identify novel molecular targets for early screening and therapeutic intervention for this lethal malignancy.

Original languageEnglish (US)
Pages (from-to)283-297
Number of pages15
JournalMinerva Gastroenterologica e Dietologica
Volume58
Issue number4
StatePublished - Dec 2012

Keywords

  • Inflammation
  • Neoplasms
  • Obesity
  • Pancreatic neoplasms
  • Pancreatitis
  • Smoking

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Gastroenterology

Fingerprint Dive into the research topics of 'Discovering the route from inflammation to pancreatic cancer'. Together they form a unique fingerprint.

Cite this