TY - JOUR
T1 - Discovery of 1,4-didydroxy-2-naphthoate prenyltransferase inhibitors
T2 - New drug leads for multidrug-resistant gram-positive pathogens
AU - Kurosu, Michio
AU - Narayanasamy, Prabagaran
AU - Biswas, Kallolmay
AU - Dhiman, Rakesh
AU - Crick, Dean C.
PY - 2007/8/23
Y1 - 2007/8/23
N2 - Since utilization of menaquinone in the electron transport system is a characteristic of Gram-positive organisms, the 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA) inhibitors 1a and 2a act as selective antibacterial agents against organisms such as methicillin-resistant Stapylococcus aureus (MRSA), Staphylococcus epidermidis (MRSE), and Mycobacterium spp. Growth of drug-resistant Gram-positive organisms was sensitive to the MenA inhibitors, indicating that menaquinone synthesis is a valid new drug target in Gram-positive organisms.
AB - Since utilization of menaquinone in the electron transport system is a characteristic of Gram-positive organisms, the 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA) inhibitors 1a and 2a act as selective antibacterial agents against organisms such as methicillin-resistant Stapylococcus aureus (MRSA), Staphylococcus epidermidis (MRSE), and Mycobacterium spp. Growth of drug-resistant Gram-positive organisms was sensitive to the MenA inhibitors, indicating that menaquinone synthesis is a valid new drug target in Gram-positive organisms.
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U2 - 10.1021/jm070638m
DO - 10.1021/jm070638m
M3 - Article
C2 - 17658779
AN - SCOPUS:34548118698
SN - 0022-2623
VL - 50
SP - 3973
EP - 3975
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
IS - 17
ER -