Discovery of 1,4-didydroxy-2-naphthoate prenyltransferase inhibitors: New drug leads for multidrug-resistant gram-positive pathogens

Michio Kurosu, Prabagaran Narayanasamy, Kallolmay Biswas, Rakesh Dhiman, Dean C. Crick

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Since utilization of menaquinone in the electron transport system is a characteristic of Gram-positive organisms, the 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA) inhibitors 1a and 2a act as selective antibacterial agents against organisms such as methicillin-resistant Stapylococcus aureus (MRSA), Staphylococcus epidermidis (MRSE), and Mycobacterium spp. Growth of drug-resistant Gram-positive organisms was sensitive to the MenA inhibitors, indicating that menaquinone synthesis is a valid new drug target in Gram-positive organisms.

Original languageEnglish (US)
Pages (from-to)3973-3975
Number of pages3
JournalJournal of Medicinal Chemistry
Volume50
Issue number17
DOIs
StatePublished - Aug 23 2007

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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