Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: Development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia

Uyen Le, Bruce J. Melancon, Thomas M. Bridges, Paige N. Vinson, Thomas J. Utley, Atin Lamsal, Alice L. Rodriguez, Daryl Venable, Douglas J. Sheffler, Carrie K. Jones, Anna L. Blobaum, Michael R. Wood, J. Scott Daniels, P. Jeffrey Conn, Colleen M. Niswender, Craig W. Lindsley, Corey R. Hopkins

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