Disseminated bacille Calmette-Guerin infection in an infant with a novel deletion in the interferon-gamma receptor gene

J. A. Cunningham; J. D. Kellner; P. J. Bridge; C. L. Trevenen; D. R. McLeod; H. D. Davies

Disseminated bacille Calmette-Guerin infection in an infant with a novel deletion in the interferon-gamma receptor gene

J. A. Cunningham, J. D. Kellner, P. J. Bridge, C. L. Trevenen, D. R. McLeod, H. D. Davies

Research output: Contribution to journal › Article › peer-review

Abstract

Six weeks after receiving BCG vaccination, a Canadian aboriginal infant presented with suspected sepsis, lymph-adenopathy and hepatosplenomegaly. Lymph node biopsy revealed macrophages filled with acid-fast bacilli. Mycobacterium bovis was cultured from tissue specimens and there was evidence of concomitant cytomegalovirus disease. The infant died of disseminated BCG infection. A novel deletion at nucleotide 165 in the interferon-gamma receptor (IFN-γR1) was identified. The incidence of this mutation in the aboriginal population and the impact on the heterozygous state are unknown.

Original language	English (US)
Pages (from-to)	791-794
Number of pages	4
Journal	International Journal of Tuberculosis and Lung Disease
Volume	4
Issue number	8
State	Published - 2000
Externally published	Yes

Keywords

BCG
Immunodeficiency
Interferon-gamma receptor

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Infectious Diseases

Cite this

@article{91527e11eb5e42e78dd4afe1049cc3cd,

title = "Disseminated bacille Calmette-Guerin infection in an infant with a novel deletion in the interferon-gamma receptor gene",

abstract = "Six weeks after receiving BCG vaccination, a Canadian aboriginal infant presented with suspected sepsis, lymph-adenopathy and hepatosplenomegaly. Lymph node biopsy revealed macrophages filled with acid-fast bacilli. Mycobacterium bovis was cultured from tissue specimens and there was evidence of concomitant cytomegalovirus disease. The infant died of disseminated BCG infection. A novel deletion at nucleotide 165 in the interferon-gamma receptor (IFN-γR1) was identified. The incidence of this mutation in the aboriginal population and the impact on the heterozygous state are unknown.",

keywords = "BCG, Immunodeficiency, Interferon-gamma receptor",

author = "Cunningham, {J. A.} and Kellner, {J. D.} and Bridge, {P. J.} and Trevenen, {C. L.} and McLeod, {D. R.} and Davies, {H. D.}",

year = "2000",

language = "English (US)",

volume = "4",

pages = "791--794",

journal = "International Journal of Tuberculosis and Lung Disease",

issn = "1027-3719",

publisher = "International Union Against Tuberculosis and Lung Disease ",

number = "8",

}

TY - JOUR

T1 - Disseminated bacille Calmette-Guerin infection in an infant with a novel deletion in the interferon-gamma receptor gene

AU - Cunningham, J. A.

AU - Kellner, J. D.

AU - Bridge, P. J.

AU - Trevenen, C. L.

AU - McLeod, D. R.

AU - Davies, H. D.

PY - 2000

Y1 - 2000

N2 - Six weeks after receiving BCG vaccination, a Canadian aboriginal infant presented with suspected sepsis, lymph-adenopathy and hepatosplenomegaly. Lymph node biopsy revealed macrophages filled with acid-fast bacilli. Mycobacterium bovis was cultured from tissue specimens and there was evidence of concomitant cytomegalovirus disease. The infant died of disseminated BCG infection. A novel deletion at nucleotide 165 in the interferon-gamma receptor (IFN-γR1) was identified. The incidence of this mutation in the aboriginal population and the impact on the heterozygous state are unknown.

AB - Six weeks after receiving BCG vaccination, a Canadian aboriginal infant presented with suspected sepsis, lymph-adenopathy and hepatosplenomegaly. Lymph node biopsy revealed macrophages filled with acid-fast bacilli. Mycobacterium bovis was cultured from tissue specimens and there was evidence of concomitant cytomegalovirus disease. The infant died of disseminated BCG infection. A novel deletion at nucleotide 165 in the interferon-gamma receptor (IFN-γR1) was identified. The incidence of this mutation in the aboriginal population and the impact on the heterozygous state are unknown.

KW - BCG

KW - Immunodeficiency

KW - Interferon-gamma receptor

UR - http://www.scopus.com/inward/record.url?scp=0033841836&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033841836&partnerID=8YFLogxK

M3 - Article

C2 - 10949334

AN - SCOPUS:0033841836

SN - 1027-3719

VL - 4

SP - 791

EP - 794

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 8

ER -

Disseminated bacille Calmette-Guerin infection in an infant with a novel deletion in the interferon-gamma receptor gene

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this