Diuretics and Hypertension in Black Adults

David W. Hawkins, Merwin R. Dieckmann, Ronnie D. Horner

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


A randomized controlled, single-blind trial was conducted to compare the effectiveness of a high-dose diuretic with a combination of a diuretic and metoprolol in black adults with hypertension. All subjects were first treated with 50 mg/d of hydrochlorothiazide for four weeks. Only subjects with a diastolic blood pressure of 95 mm Hg or higher at the end of this four-week period entered the randomized trial. We hypothesized that black patients with uncontrolled hypertension and low plasma renin activity on usual-dose hydrochlorothiazide therapy (ie, 50 mg/d) would respond better to higher doses of hydrochlorothiazide (ie, 100 to 150 mg/d) than to a usual-dose diuretic and metoprolol. Diuretic-metoprolol combination therapy was significantly more effective than high-dose diuretic therapy regardless of plasma renin status.

Original languageEnglish (US)
Pages (from-to)803-805
Number of pages3
JournalArchives of Internal Medicine
Issue number4
StatePublished - Apr 1988
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine


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