TY - JOUR
T1 - DNA damage induced by endogenous aldehydes
T2 - Current state of knowledge
AU - Voulgaridou, Georgia Persephoni
AU - Anestopoulos, Ioannis
AU - Franco, Rodrigo
AU - Panayiotidis, Mihalis I.
AU - Pappa, Aglaia
N1 - Funding Information:
This work was supported, in part, by the National Institutes of Health (Grant P20RR17675 ), Centers of Biomedical Research Excellence (COBRE) and Layman Award from the University of Nebraska-Lincoln (Dr. Franco), a Marie Curie International Reintegration Grant within the 6th European Community Framework Program ( MIRG-CT-2006-036585 ) (Dr. Pappa), and the School of Community Health Sciences and a Junior Faculty Research Award from the University of Nevada-Reno (Dr. Panayiotidis).
PY - 2011/6/3
Y1 - 2011/6/3
N2 - DNA damage plays a major role in various pathophysiological conditions including carcinogenesis, aging, inflammation, diabetes and neurodegenerative diseases. Oxidative stress and cell processes such as lipid peroxidation and glycation induce the formation of highly reactive endogenous aldehydes that react directly with DNA, form aldehyde-derived DNA adducts and lead to DNA damage. In occasion of persistent conditions that influence the formation and accumulation of aldehyde-derived DNA adducts the resulting unrepaired DNA damage causes deregulation of cell homeostasis and thus significantly contributes to disease phenotype. Some of the most highly reactive aldehydes produced endogenously are 4-hydroxy-2-nonenal, malondialdehyde, acrolein, crotonaldehyde and methylglyoxal. The mutagenic and carcinogenic effects associated with the elevated levels of these reactive aldehydes, especially, under conditions of stress, are attributed to their capability of causing directly modification of DNA bases or yielding promutagenic exocyclic adducts. In this review, we discuss the current knowledge on DNA damage induced by endogenously produced reactive aldehydes in relation to the pathophysiology of human diseases.
AB - DNA damage plays a major role in various pathophysiological conditions including carcinogenesis, aging, inflammation, diabetes and neurodegenerative diseases. Oxidative stress and cell processes such as lipid peroxidation and glycation induce the formation of highly reactive endogenous aldehydes that react directly with DNA, form aldehyde-derived DNA adducts and lead to DNA damage. In occasion of persistent conditions that influence the formation and accumulation of aldehyde-derived DNA adducts the resulting unrepaired DNA damage causes deregulation of cell homeostasis and thus significantly contributes to disease phenotype. Some of the most highly reactive aldehydes produced endogenously are 4-hydroxy-2-nonenal, malondialdehyde, acrolein, crotonaldehyde and methylglyoxal. The mutagenic and carcinogenic effects associated with the elevated levels of these reactive aldehydes, especially, under conditions of stress, are attributed to their capability of causing directly modification of DNA bases or yielding promutagenic exocyclic adducts. In this review, we discuss the current knowledge on DNA damage induced by endogenously produced reactive aldehydes in relation to the pathophysiology of human diseases.
KW - 4-Hydroxy-2-nonenal (4-HNE)
KW - 4-Oxo-trans-2-nonenal (4-ONE)
KW - Acetaldehyde (AA)
KW - Acrolein
KW - Aldehydes
KW - Crotonaldehyde (Cr)
KW - DNA damage
KW - Formaldehyde (FA)
KW - Glyceraldehyde (GA)
KW - Glyoxal
KW - Malondialdehyde (MDA)
KW - Methylglyoxal (MG)
KW - Oxidative stress
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U2 - 10.1016/j.mrfmmm.2011.03.006
DO - 10.1016/j.mrfmmm.2011.03.006
M3 - Review article
C2 - 21419140
AN - SCOPUS:79956195255
SN - 0027-5107
VL - 711
SP - 13
EP - 27
JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
IS - 1-2
ER -