DNA microarrays and human brain disorders

Károly Mirnics, David A. Lewis, Pat Levitt

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

Gene delivery to the brain presents several unique challenges based on limited and risky access through the skull/vertebrae; sensitivity to volumetric changes; critical nuclei controlling life-functions; and a highly specialized blood-brain-barrier designed to keep particles and viruses out. The architectural heterogeneity of the neurocircuitry in the central nervous system (CNS) provides the opportunity to target focal areas of disease pathogenesis, but further complicates delivery for more global CNS diseases, such as brain tumors. This chapter will focus on modes of gene delivery to the nervous system, including vectors, cells, and routes of administration.

Original languageEnglish (US)
Title of host publicationMethods in Genomic Neuroscience
PublisherCRC Press
Pages171-206
Number of pages36
ISBN (Electronic)9781420038477
ISBN (Print)0849323975, 9780849323973
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Mirnics, K., Lewis, D. A., & Levitt, P. (2001). DNA microarrays and human brain disorders. In Methods in Genomic Neuroscience (pp. 171-206). CRC Press.