DNA polymerases at the eukaryotic fork-20 years later

Youri I. Pavlov; Polina V. Shcherbakova

doi:10.1016/j.mrfmmm.2009.08.002

DNA polymerases at the eukaryotic fork-20 years later

Youri I. Pavlov, Polina V. Shcherbakova

Research output: Contribution to journal › Review article › peer-review

77 Scopus citations

Abstract

Function of the eukaryotic genome depends on efficient and accurate replication of anti-parallel DNA strands. Eukaryotic DNA polymerases have different properties adapted to perform a wide spectrum of DNA transactions. Here we focus on major players in the bulk replication, DNA polymerases of the B-family. We review the organization of the replication fork in eukaryotes in a historical perspective, analyze contemporary models and propose a new integrative model of the fork.

Original language	English (US)
Pages (from-to)	45-53
Number of pages	9
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	685
Issue number	1-2
DOIs	https://doi.org/10.1016/j.mrfmmm.2009.08.002
State	Published - Mar 1 2010

Keywords

DNA polymerases
Replication fork
Replication origins

ASJC Scopus subject areas

Molecular Biology
Genetics
Health, Toxicology and Mutagenesis

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10.1016/j.mrfmmm.2009.08.002

Cite this

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title = "DNA polymerases at the eukaryotic fork-20 years later",

abstract = "Function of the eukaryotic genome depends on efficient and accurate replication of anti-parallel DNA strands. Eukaryotic DNA polymerases have different properties adapted to perform a wide spectrum of DNA transactions. Here we focus on major players in the bulk replication, DNA polymerases of the B-family. We review the organization of the replication fork in eukaryotes in a historical perspective, analyze contemporary models and propose a new integrative model of the fork.",

keywords = "DNA polymerases, Replication fork, Replication origins",

author = "Pavlov, {Youri I.} and Shcherbakova, {Polina V.}",

note = "Funding Information: We thank Peter Burgers for reading the manuscript and providing constructive comments despite the difference in the views on the prevailing replication mechanisms. We thank Tahir Tahirov, Tom Kunkel, Dmitry Gordenin, Erik Johansson, and Farid Kadyrov for valuable discussions of the topics related to the current review. We thank Victoria Liston for expert technical assistance in experiments. The work in the authors{\textquoteright} laboratories is supported in part by the NIH grant CA129925 , Eppley Institute Pilot grant and NE DHHS 2008 grant LB506 (to Y.I.P.) and the NIH grant ES015869 (to P.V.S.).",

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AU - Pavlov, Youri I.

AU - Shcherbakova, Polina V.

N1 - Funding Information: We thank Peter Burgers for reading the manuscript and providing constructive comments despite the difference in the views on the prevailing replication mechanisms. We thank Tahir Tahirov, Tom Kunkel, Dmitry Gordenin, Erik Johansson, and Farid Kadyrov for valuable discussions of the topics related to the current review. We thank Victoria Liston for expert technical assistance in experiments. The work in the authors’ laboratories is supported in part by the NIH grant CA129925 , Eppley Institute Pilot grant and NE DHHS 2008 grant LB506 (to Y.I.P.) and the NIH grant ES015869 (to P.V.S.).

PY - 2010/3/1

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N2 - Function of the eukaryotic genome depends on efficient and accurate replication of anti-parallel DNA strands. Eukaryotic DNA polymerases have different properties adapted to perform a wide spectrum of DNA transactions. Here we focus on major players in the bulk replication, DNA polymerases of the B-family. We review the organization of the replication fork in eukaryotes in a historical perspective, analyze contemporary models and propose a new integrative model of the fork.

AB - Function of the eukaryotic genome depends on efficient and accurate replication of anti-parallel DNA strands. Eukaryotic DNA polymerases have different properties adapted to perform a wide spectrum of DNA transactions. Here we focus on major players in the bulk replication, DNA polymerases of the B-family. We review the organization of the replication fork in eukaryotes in a historical perspective, analyze contemporary models and propose a new integrative model of the fork.

KW - DNA polymerases

KW - Replication fork

KW - Replication origins

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DNA polymerases at the eukaryotic fork-20 years later

Abstract

Keywords

ASJC Scopus subject areas

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