DNA replication fidelity and cancer

Bradley D. Preston, Tina M. Albertson, Alan J. Herr

Research output: Contribution to journalReview articlepeer-review

84 Scopus citations

Abstract

Cancer is fueled by mutations and driven by adaptive selection. Normal cells avoid deleterious mutations by replicating their genomes with extraordinary accuracy. Here we review the pathways governing DNA replication fidelity and discuss evidence implicating replication errors (point mutation instability or PIN) in carcinogenesis.

Original languageEnglish (US)
Pages (from-to)281-293
Number of pages13
JournalSeminars in Cancer Biology
Volume20
Issue number5
DOIs
StatePublished - Oct 2010
Externally publishedYes

Keywords

  • Cancer
  • DNA polymerase
  • Mismatch repair
  • Mutator
  • Proofreading

ASJC Scopus subject areas

  • Cancer Research

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