@article{12efe91122544b70a5421e86c7d87629,
title = "DNA replication fidelity and cancer",
abstract = "Cancer is fueled by mutations and driven by adaptive selection. Normal cells avoid deleterious mutations by replicating their genomes with extraordinary accuracy. Here we review the pathways governing DNA replication fidelity and discuss evidence implicating replication errors (point mutation instability or PIN) in carcinogenesis.",
keywords = "Cancer, DNA polymerase, Mismatch repair, Mutator, Proofreading",
author = "Preston, {Bradley D.} and Albertson, {Tina M.} and Herr, {Alan J.}",
note = "Funding Information: Our sincere thanks go to Larry Loeb for his critical insight and creative spirit. We also thank past and present laboratory members for valuable discussions and experimental contributions. Our research was supported by the National Institutes of Health ( R01 ES09927 , R01 CA098243 , R01 CA111582 , P20 CA103728 , P01 AG01751 and P01 CA77852 ) and the National Institute of Environmental Health Sciences-sponsored Center for Ecogenetics and Environmental Health at the University of Washington ( P30 ES07033 ). Tina Albertson was supported by a Young Investigators Award from Seattle Children's Hospital and Regional Medical Center and is a St. Baldrick's Foundation Scholar. Alan Herr holds a Hitchings-Elion Fellowship from the Burroughs Wellcome Fund.",
year = "2010",
month = oct,
doi = "10.1016/j.semcancer.2010.10.009",
language = "English (US)",
volume = "20",
pages = "281--293",
journal = "Seminars in Cancer Biology",
issn = "1044-579X",
publisher = "Academic Press Inc.",
number = "5",
}