Abstract
Protein overproduction in microbes frequently results in protein misfolding and aggregation though the molecular basis for this process is unclear. The HSP70 chaperonin, DnaK, was identified as an important factor controlling heterologous protein aggregation in Escherichia coli. Cooverproduction of DnaK significantly reduced human growth hormone (HGH) protein inclusion body formation and the extent of HGH aggregation.
Original language | English (US) |
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Pages (from-to) | 301-304 |
Number of pages | 4 |
Journal | Bio/Technology |
Volume | 10 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1992 |
ASJC Scopus subject areas
- Biotechnology