DnaK-Mediated alterations in human growth hormone protein inclusion bodies

Paul Blum, Mark Velligan, Norman Lin, Abdul Matin

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Protein overproduction in microbes frequently results in protein misfolding and aggregation though the molecular basis for this process is unclear. The HSP70 chaperonin, DnaK, was identified as an important factor controlling heterologous protein aggregation in Escherichia coli. Cooverproduction of DnaK significantly reduced human growth hormone (HGH) protein inclusion body formation and the extent of HGH aggregation.

Original languageEnglish (US)
Pages (from-to)301-304
Number of pages4
JournalBio/Technology
Volume10
Issue number3
DOIs
StatePublished - Mar 1992

ASJC Scopus subject areas

  • Biotechnology

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