Abstract
Acidic fibroblast growth factor (aFGF), basic fibroblast growth factor (bFGF), transforming growth factor alpha (TGF-α), transforming growth factor beta (TGF-ß), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF165), tumor necrosis factor alpha (TNF-α), and platelet-derived growth factor BB (PDGF-BB) were incorporated into slow release polymers and implanted in the rabbit cornea as an assay for angiogenesis activity. VEGF and low doses of PDGF-BB were direct angiogenesis factors, stimulating endothelial cells to form capillaries in the absence of inflammation. TGF-ß was an indirect angiogenesis factor, eliciting angiogenesis through the recruitment of inflammatory cell mediators. TGF-α and EGF were "bifunctional" angiogenesis factors. Both factors recruited inflammatory cells prior to angiogenesis, but when the inflammation was blocked, angiogenesis still proceeded. Acidic FGF, bFGF and TNF-α were non-angiogenic.
Original language | English (US) |
---|---|
Pages (from-to) | 1-14 |
Number of pages | 14 |
Journal | Wounds |
Volume | 9 |
Issue number | 1 |
State | Published - Jan 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- General Medicine