Do growth factors stimulate angiogenesis? A comparison of putative angiogenesis factors

Gregg D. Phillips, A. Marika Stone, Julie C. Schultz, Bryan D. Jones, Margot L. Goodkin, Mark J. Lisowski, Russell A. Whitehead, Vance D. Fiegel, David R. Knighton

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Acidic fibroblast growth factor (aFGF), basic fibroblast growth factor (bFGF), transforming growth factor alpha (TGF-α), transforming growth factor beta (TGF-ß), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF165), tumor necrosis factor alpha (TNF-α), and platelet-derived growth factor BB (PDGF-BB) were incorporated into slow release polymers and implanted in the rabbit cornea as an assay for angiogenesis activity. VEGF and low doses of PDGF-BB were direct angiogenesis factors, stimulating endothelial cells to form capillaries in the absence of inflammation. TGF-ß was an indirect angiogenesis factor, eliciting angiogenesis through the recruitment of inflammatory cell mediators. TGF-α and EGF were "bifunctional" angiogenesis factors. Both factors recruited inflammatory cells prior to angiogenesis, but when the inflammation was blocked, angiogenesis still proceeded. Acidic FGF, bFGF and TNF-α were non-angiogenic.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
Issue number1
StatePublished - Jan 1997

ASJC Scopus subject areas

  • Surgery
  • Medical–Surgical


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