Do growth factors stimulate angiogenesis? A comparison of putative angiogenesis factors

Gregg D. Phillips; A. Marika Stone; Julie C. Schultz; Bryan D. Jones; Margot L. Goodkin; Mark J. Lisowski; Russell A. Whitehead; Vance D. Fiegel; David R. Knighton

Do growth factors stimulate angiogenesis? A comparison of putative angiogenesis factors

Gregg D. Phillips, A. Marika Stone, Julie C. Schultz, Bryan D. Jones, Margot L. Goodkin, Mark J. Lisowski, Russell A. Whitehead, Vance D. Fiegel, David R. Knighton

Anesthesiology

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Acidic fibroblast growth factor (aFGF), basic fibroblast growth factor (bFGF), transforming growth factor alpha (TGF-α), transforming growth factor beta (TGF-ß), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF₁₆₅), tumor necrosis factor alpha (TNF-α), and platelet-derived growth factor BB (PDGF-BB) were incorporated into slow release polymers and implanted in the rabbit cornea as an assay for angiogenesis activity. VEGF and low doses of PDGF-BB were direct angiogenesis factors, stimulating endothelial cells to form capillaries in the absence of inflammation. TGF-ß was an indirect angiogenesis factor, eliciting angiogenesis through the recruitment of inflammatory cell mediators. TGF-α and EGF were "bifunctional" angiogenesis factors. Both factors recruited inflammatory cells prior to angiogenesis, but when the inflammation was blocked, angiogenesis still proceeded. Acidic FGF, bFGF and TNF-α were non-angiogenic.

Original language	English (US)
Pages (from-to)	1-14
Number of pages	14
Journal	Wounds
Volume	9
Issue number	1
State	Published - Jan 1997

ASJC Scopus subject areas

Surgery
Medical–Surgical

Cite this

@article{12b53a070fe944fe8190758ae31e9054,

title = "Do growth factors stimulate angiogenesis? A comparison of putative angiogenesis factors",

abstract = "Acidic fibroblast growth factor (aFGF), basic fibroblast growth factor (bFGF), transforming growth factor alpha (TGF-α), transforming growth factor beta (TGF-{\ss}), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF165), tumor necrosis factor alpha (TNF-α), and platelet-derived growth factor BB (PDGF-BB) were incorporated into slow release polymers and implanted in the rabbit cornea as an assay for angiogenesis activity. VEGF and low doses of PDGF-BB were direct angiogenesis factors, stimulating endothelial cells to form capillaries in the absence of inflammation. TGF-{\ss} was an indirect angiogenesis factor, eliciting angiogenesis through the recruitment of inflammatory cell mediators. TGF-α and EGF were {"}bifunctional{"} angiogenesis factors. Both factors recruited inflammatory cells prior to angiogenesis, but when the inflammation was blocked, angiogenesis still proceeded. Acidic FGF, bFGF and TNF-α were non-angiogenic.",

author = "Phillips, {Gregg D.} and Stone, {A. Marika} and Schultz, {Julie C.} and Jones, {Bryan D.} and Goodkin, {Margot L.} and Lisowski, {Mark J.} and Whitehead, {Russell A.} and Fiegel, {Vance D.} and Knighton, {David R.}",

year = "1997",

month = jan,

language = "English (US)",

volume = "9",

pages = "1--14",

journal = "Wounds",

issn = "1044-7946",

publisher = "HMP Communications",

number = "1",

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TY - JOUR

T1 - Do growth factors stimulate angiogenesis? A comparison of putative angiogenesis factors

AU - Phillips, Gregg D.

AU - Stone, A. Marika

AU - Schultz, Julie C.

AU - Jones, Bryan D.

AU - Goodkin, Margot L.

AU - Lisowski, Mark J.

AU - Whitehead, Russell A.

AU - Fiegel, Vance D.

AU - Knighton, David R.

PY - 1997/1

Y1 - 1997/1

N2 - Acidic fibroblast growth factor (aFGF), basic fibroblast growth factor (bFGF), transforming growth factor alpha (TGF-α), transforming growth factor beta (TGF-ß), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF165), tumor necrosis factor alpha (TNF-α), and platelet-derived growth factor BB (PDGF-BB) were incorporated into slow release polymers and implanted in the rabbit cornea as an assay for angiogenesis activity. VEGF and low doses of PDGF-BB were direct angiogenesis factors, stimulating endothelial cells to form capillaries in the absence of inflammation. TGF-ß was an indirect angiogenesis factor, eliciting angiogenesis through the recruitment of inflammatory cell mediators. TGF-α and EGF were "bifunctional" angiogenesis factors. Both factors recruited inflammatory cells prior to angiogenesis, but when the inflammation was blocked, angiogenesis still proceeded. Acidic FGF, bFGF and TNF-α were non-angiogenic.

AB - Acidic fibroblast growth factor (aFGF), basic fibroblast growth factor (bFGF), transforming growth factor alpha (TGF-α), transforming growth factor beta (TGF-ß), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF165), tumor necrosis factor alpha (TNF-α), and platelet-derived growth factor BB (PDGF-BB) were incorporated into slow release polymers and implanted in the rabbit cornea as an assay for angiogenesis activity. VEGF and low doses of PDGF-BB were direct angiogenesis factors, stimulating endothelial cells to form capillaries in the absence of inflammation. TGF-ß was an indirect angiogenesis factor, eliciting angiogenesis through the recruitment of inflammatory cell mediators. TGF-α and EGF were "bifunctional" angiogenesis factors. Both factors recruited inflammatory cells prior to angiogenesis, but when the inflammation was blocked, angiogenesis still proceeded. Acidic FGF, bFGF and TNF-α were non-angiogenic.

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AN - SCOPUS:0031481468

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VL - 9

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Do growth factors stimulate angiogenesis? A comparison of putative angiogenesis factors

Abstract

ASJC Scopus subject areas

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