Donor-derived tuberculosis among solid organ transplant recipients in the United States—2008 to 2018

Maricar Malinis, Ricardo M. LaHoz, Gabriel Vece, Pallavi Annambhotla, Saima Aslam, Sridhar V. Basavaraju, Jamie Bucio, Lara Danziger-Isakov, Diana F. Florescu, Jefferson M. Jones, Meenakshi Rana, Cameron R. Wolfe, Marian G. Michaels

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Mycobacterium tuberculosis can be transmitted via organ donation and result in severe outcomes. To better understand donor-derived tuberculosis (DDTB), all potential transmissions reported to the Organ Procurement and Transplantation Network (OPTN) Ad Hoc Disease Transmission Advisory Committee between 2008 and 2018 were analyzed. Among 51 total reports, nine (17%) (9 donors/35 recipients) had ≥ 1 recipient with proven/probable disease transmission. Of these, eight were reported due to recipient disease, and one was reported due to a positive donor result. Proven/probable DDTB transmissions were reported in six lung and five nonlung recipients. The median time to diagnosis was 104 days posttransplant (range 0–165 days). Pulmonary TB, extrapulmonary TB, pulmonary plus extrapulmonary TB, and asymptomatic TB infection with positive interferon-gamma release assay were present in five, three, one, and two recipients, respectively. All recipients received treatment and survived except for one whose death was not attributed to TB. All donors associated with proven/probable DDTB had ≥ 1 TB risk factor. Six were born in a TB-endemic country, five had traveled to a TB-endemic country, three had been incarcerated, and three had latent TB infection. These cases highlight the importance of evaluating donors for TB based on risk factors. Early posttransplant TB in organ recipients of donors with TB risk factors requires prompt reporting to OPTN to identify other potential affected recipients and implement timely treatment interventions.

Original languageEnglish (US)
Article numbere13800
JournalTransplant Infectious Disease
Issue number2
StatePublished - Apr 2022


  • donor-derived infections
  • transplant
  • tuberculosis

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases


Dive into the research topics of 'Donor-derived tuberculosis among solid organ transplant recipients in the United States—2008 to 2018'. Together they form a unique fingerprint.

Cite this