Drug delivery strategies for cathepsin inhibitors in joint diseases

Dong Wang, Dieter Brömme

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Cathepsins play important roles in the development of joint and bone diseases such as osteoporosis, rheumatoid arthritis (RA) and osteoarthritis (OA). Cathepsin inhibitors are presently in development and clinical testing for use as novel disease-modifying drugs for the improved treatment of osteoporosis. They may also be applicable for the treatment of joint diseases. However, some barriers still hamper their clinical applications in these indications. Based on pathophysiological features of RA and OA, the authors discuss six potential drug delivery strategies for the effective delivery of cathepsin inhibitors or other antiarthritic drugs to the arthritic joint tissue. Successful application of these strategies may significantly contribute to a more effective and safe treatment of RA and OA.

Original languageEnglish (US)
Pages (from-to)1015-1028
Number of pages14
JournalExpert Opinion on Drug Delivery
Volume2
Issue number6
DOIs
StatePublished - Nov 2005

Keywords

  • Cartilage
  • Cathepsin
  • Drug delivery
  • Inhibitor
  • Joint
  • Osteoarthritis
  • Osteoporosis
  • Rheumatoid arthritis
  • Subchondral bone

ASJC Scopus subject areas

  • Pharmaceutical Science

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