Dual activation of the inositol-triphosphate-calcium and cyclic nucleotide intracellular signaling systems by adrenocorticotropin in rat adrenal cells

Robert V. Farese, Nenad Rosic, Jeffrey Babischkin, Margaret G. Farese, Richard Foster, John S. Davis

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Hormones which primarily utilize cAMP as their intracellular "second messenger" are generally not thought to activate the IP3-Ca++ signalling system. Presently, we show that ACTH, at certain concentrations, can activate both the cAMP and IP3-Ca++ intracellular signalling systems.

Original languageEnglish (US)
Pages (from-to)742-748
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume135
Issue number3
DOIs
StatePublished - Mar 28 1986

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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