Dual temperature multi-organ recovery from a Maastricht category III donor after circulatory death

G. C. Oniscu, A. Siddique, J. Dark

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Donation after circulatory death (DCD) makes a significant contribution to the transplant activity but is associated with significantly lower organ recovery rates and poorer function for the abdominal extra-renal organs compared with donation after brain death. Traditionally, DCD organ recovery involves cold thoracic and abdominal perfusion with a rapid removal of organs in order to minimize the ischemic damage. Novel approaches to organ recovery and preservation include the use of normothermic regional perfusion in the donor and ex vivo organ preservation. We report a new technique for multi-organ recovery from Maastricht category III donors with abdominal normothermic perfusion and concomitant cold lung flushing which allows a rapid removal of the lungs with preservation of the abdominal normothermic circulation throughout the thoracic procurement. This approach could lead to an increased organ recovery and better function for the abdominal organs. The authors report a technique that allows dual temperature (cold thoracic - normothermic abdominal) organ recovery from controlled donation after circulatory death.

Original languageEnglish (US)
Pages (from-to)2181-2186
Number of pages6
JournalAmerican Journal of Transplantation
Volume14
Issue number9
DOIs
StatePublished - Sep 2014

Keywords

  • Clinical research
  • donation after circulatory death (DCD)
  • donors and donation
  • extracorporeal membrane oxygenation (ECMO)
  • organ perfusion and preservation
  • organ procurement and allocation
  • organ transplantation in general
  • practice
  • surgical technique

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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