TY - JOUR
T1 - Dysbiosis and Intestinal Barrier Dysfunction in Pediatric Congenital Heart Disease Is Exacerbated Following Cardiopulmonary Bypass
AU - Salomon, Jeffrey
AU - Ericsson, Aaron
AU - Price, Amber
AU - Manithody, Chandrashekhara
AU - Murry, Daryl J.
AU - Chhonker, Yashpal S.
AU - Buchanan, Paula
AU - Lindsey, Merry L.
AU - Singh, Amar B.
AU - Jain, Ajay K.
N1 - Funding Information:
This work was supported by an internal Fleur de Lis $25,000 grant from Saint Louis University School of Medicine. Dr. Lindsey is a Stokes-Shackleford Professor at the University of Nebraska Medical Center. This research was supported by funding from the National Institutes of Health under awards DK121046-01, DK124950-01, DK98623-01A1, DK124095-01A1, HL129823, HL137319, and OD019924-01 and from the U.S. Department of Veterans Affairs Office of Research and Development under awards, and 5I01BX000505. The content is solely the responsibility of the authors and does not necessarily represent the official views of any funding agencies. All authors have reviewed and approved this article. The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
Publisher Copyright:
© 2021 The Authors
PY - 2021/4
Y1 - 2021/4
N2 - There are no data evaluating the microbiome in congenital heart disease following cardiopulmonary bypass. The authors evaluated patients with congenital heart disease undergoing cardiopulmonary bypass and noncardiac patients undergoing surgery without bypass. Patients with congenital heart disease had differences in baseline microbiome compared with control subjects, and this was exacerbated following surgery with bypass. Markers of barrier dysfunction were similar for both groups at baseline, and surgery with bypass induced significant intestinal barrier dysfunction compared with control subjects. This study offers novel evidence of alterations of the microbiome in congenital heart disease and exacerbation along with intestinal barrier dysfunction following cardiopulmonary bypass.
AB - There are no data evaluating the microbiome in congenital heart disease following cardiopulmonary bypass. The authors evaluated patients with congenital heart disease undergoing cardiopulmonary bypass and noncardiac patients undergoing surgery without bypass. Patients with congenital heart disease had differences in baseline microbiome compared with control subjects, and this was exacerbated following surgery with bypass. Markers of barrier dysfunction were similar for both groups at baseline, and surgery with bypass induced significant intestinal barrier dysfunction compared with control subjects. This study offers novel evidence of alterations of the microbiome in congenital heart disease and exacerbation along with intestinal barrier dysfunction following cardiopulmonary bypass.
KW - bacterial interactions
KW - cardiovascular disease
KW - enteric bacterial microflora
KW - intestinal barrier function
KW - intestinal microbiology
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U2 - 10.1016/j.jacbts.2020.12.012
DO - 10.1016/j.jacbts.2020.12.012
M3 - Article
C2 - 33997519
AN - SCOPUS:85104354495
SN - 2452-302X
VL - 6
SP - 311
EP - 327
JO - JACC: Basic to Translational Science
JF - JACC: Basic to Translational Science
IS - 4
ER -