Dysbiosis and Intestinal Barrier Dysfunction in Pediatric Congenital Heart Disease Is Exacerbated Following Cardiopulmonary Bypass

Jeffrey Salomon; Aaron Ericsson; Amber Price; Chandrashekhara Manithody; Daryl J. Murry; Yashpal S. Chhonker; Paula Buchanan; Merry L. Lindsey; Amar B. Singh; Ajay K. Jain

doi:10.1016/j.jacbts.2020.12.012

Dysbiosis and Intestinal Barrier Dysfunction in Pediatric Congenital Heart Disease Is Exacerbated Following Cardiopulmonary Bypass

Jeffrey Salomon, Aaron Ericsson, Amber Price, Chandrashekhara Manithody, Daryl J. Murry, Yashpal S. Chhonker, Paula Buchanan, Merry L. Lindsey, Amar B. Singh, Ajay K. Jain

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

There are no data evaluating the microbiome in congenital heart disease following cardiopulmonary bypass. The authors evaluated patients with congenital heart disease undergoing cardiopulmonary bypass and noncardiac patients undergoing surgery without bypass. Patients with congenital heart disease had differences in baseline microbiome compared with control subjects, and this was exacerbated following surgery with bypass. Markers of barrier dysfunction were similar for both groups at baseline, and surgery with bypass induced significant intestinal barrier dysfunction compared with control subjects. This study offers novel evidence of alterations of the microbiome in congenital heart disease and exacerbation along with intestinal barrier dysfunction following cardiopulmonary bypass.

Original language	English (US)
Pages (from-to)	311-327
Number of pages	17
Journal	JACC: Basic to Translational Science
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/j.jacbts.2020.12.012
State	Published - Apr 2021

Keywords

bacterial interactions
cardiovascular disease
enteric bacterial microflora
intestinal barrier function
intestinal microbiology

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jacbts.2020.12.012

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Salomon, J., Ericsson, A., Price, A., Manithody, C., Murry, D. J., Chhonker, Y. S., Buchanan, P., Lindsey, M. L., Singh, A. B., & Jain, A. K. (2021). Dysbiosis and Intestinal Barrier Dysfunction in Pediatric Congenital Heart Disease Is Exacerbated Following Cardiopulmonary Bypass. JACC: Basic to Translational Science, 6(4), 311-327. https://doi.org/10.1016/j.jacbts.2020.12.012

Salomon, J, Ericsson, A, Price, A, Manithody, C, Murry, DJ, Chhonker, YS, Buchanan, P, Lindsey, ML, Singh, AB & Jain, AK 2021, 'Dysbiosis and Intestinal Barrier Dysfunction in Pediatric Congenital Heart Disease Is Exacerbated Following Cardiopulmonary Bypass', JACC: Basic to Translational Science, vol. 6, no. 4, pp. 311-327. https://doi.org/10.1016/j.jacbts.2020.12.012

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abstract = "There are no data evaluating the microbiome in congenital heart disease following cardiopulmonary bypass. The authors evaluated patients with congenital heart disease undergoing cardiopulmonary bypass and noncardiac patients undergoing surgery without bypass. Patients with congenital heart disease had differences in baseline microbiome compared with control subjects, and this was exacerbated following surgery with bypass. Markers of barrier dysfunction were similar for both groups at baseline, and surgery with bypass induced significant intestinal barrier dysfunction compared with control subjects. This study offers novel evidence of alterations of the microbiome in congenital heart disease and exacerbation along with intestinal barrier dysfunction following cardiopulmonary bypass.",

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Dysbiosis and Intestinal Barrier Dysfunction in Pediatric Congenital Heart Disease Is Exacerbated Following Cardiopulmonary Bypass

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Keywords

ASJC Scopus subject areas

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