Dysbiosis and Intestinal Barrier Dysfunction in Pediatric Congenital Heart Disease Is Exacerbated Following Cardiopulmonary Bypass

Jeffrey Salomon, Aaron Ericsson, Amber Price, Chandrashekhara Manithody, Daryl J. Murry, Yashpal S. Chhonker, Paula Buchanan, Merry L. Lindsey, Amar B. Singh, Ajay K. Jain

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

There are no data evaluating the microbiome in congenital heart disease following cardiopulmonary bypass. The authors evaluated patients with congenital heart disease undergoing cardiopulmonary bypass and noncardiac patients undergoing surgery without bypass. Patients with congenital heart disease had differences in baseline microbiome compared with control subjects, and this was exacerbated following surgery with bypass. Markers of barrier dysfunction were similar for both groups at baseline, and surgery with bypass induced significant intestinal barrier dysfunction compared with control subjects. This study offers novel evidence of alterations of the microbiome in congenital heart disease and exacerbation along with intestinal barrier dysfunction following cardiopulmonary bypass.

Original languageEnglish (US)
Pages (from-to)311-327
Number of pages17
JournalJACC: Basic to Translational Science
Volume6
Issue number4
DOIs
StatePublished - Apr 2021

Keywords

  • bacterial interactions
  • cardiovascular disease
  • enteric bacterial microflora
  • intestinal barrier function
  • intestinal microbiology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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