E-cadherin mediates adherens junction organization through protein kinase C

J. E. Lewis, P. J. Jensen, K. R. Johnson, M. J. Wheelock

Research output: Contribution to journalArticlepeer-review

93 Scopus citations


Cultured human keratinocytes maintained in 30 μM Ca2+ do not form adherens junctions; however, when the extracellular Ca2+ concentration is raised to 1 mM, adherens junctions form very rapidly. The formation of a junction involves the coordinate organization of intracellular and extracellular components. Cadherins have been shown to mediate this coordinate organization. In this report we show that E-cadherin organizes the various junctional components by signalling through protein kinase C.

Original languageEnglish (US)
Pages (from-to)3615-3621
Number of pages7
JournalJournal of cell science
Issue number12
StatePublished - 1994
Externally publishedYes


  • Cadherin
  • Keratinocyte
  • Protein kinase C

ASJC Scopus subject areas

  • Cell Biology


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