Cultured human keratinocytes maintained in 30 μM Ca2+ do not form adherens junctions; however, when the extracellular Ca2+ concentration is raised to 1 mM, adherens junctions form very rapidly. The formation of a junction involves the coordinate organization of intracellular and extracellular components. Cadherins have been shown to mediate this coordinate organization. In this report we show that E-cadherin organizes the various junctional components by signalling through protein kinase C.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of cell science|
|State||Published - 1994|
- Protein kinase C
ASJC Scopus subject areas
- Cell Biology