Abstract
Cultured human keratinocytes maintained in 30 μM Ca2+ do not form adherens junctions; however, when the extracellular Ca2+ concentration is raised to 1 mM, adherens junctions form very rapidly. The formation of a junction involves the coordinate organization of intracellular and extracellular components. Cadherins have been shown to mediate this coordinate organization. In this report we show that E-cadherin organizes the various junctional components by signalling through protein kinase C.
Original language | English (US) |
---|---|
Pages (from-to) | 3615-3621 |
Number of pages | 7 |
Journal | Journal of cell science |
Volume | 107 |
Issue number | 12 |
State | Published - Dec 1994 |
Externally published | Yes |
Keywords
- Cadherin
- Keratinocyte
- Protein kinase C
ASJC Scopus subject areas
- Cell Biology