TY - JOUR
T1 - Early consumption of human milk oligosaccharides is inversely related to subsequent risk of respiratory and enteric disease in infants.
AU - Stepans, Mary Beth Flanders
AU - Wilhelm, Susan L.
AU - Hertzog, Melody
AU - Rodehorst, T. Kim Callahan
AU - Blaney, Susan
AU - Clemens, Beth
AU - Polak, Josef J.
AU - Newburg, David S.
PY - 2006
Y1 - 2006
N2 - A pilot study tested the relationship between human milk oligosaccharide consumption, oligosaccharide content of feces, and subsequent disease in breastfed infants. Forty-nine (49) mother-infant pairs provided milk and fecal samples 2 weeks postpartum; infant health was assessed through 2, 6, 12, and 24 weeks. LNF-II (lacto-N-fucopentaose II), a major human milk oligosaccharide, was measured to represent levels of total oligosaccharides consumed in milk and remaining in feces. LNF-II levels in milk at 2 weeks postpartum were associated with fewer infant respiratory problems by 6 weeks (p = 0.010), as were LNF-II levels in infant feces (p = 0.003). LNF-II levels in milk at 2 weeks were also associated with fewer respiratory problems by 12 weeks (p = 0.038), and fewer enteric problems by 6 weeks (p = 0.004) and 12 weeks (p = 0.045). Thus, consumption of human milk oligosaccharides through breastfeeding, represented by LNF-II, was associated with less reported respiratory and gastrointestinal illness in infants.
AB - A pilot study tested the relationship between human milk oligosaccharide consumption, oligosaccharide content of feces, and subsequent disease in breastfed infants. Forty-nine (49) mother-infant pairs provided milk and fecal samples 2 weeks postpartum; infant health was assessed through 2, 6, 12, and 24 weeks. LNF-II (lacto-N-fucopentaose II), a major human milk oligosaccharide, was measured to represent levels of total oligosaccharides consumed in milk and remaining in feces. LNF-II levels in milk at 2 weeks postpartum were associated with fewer infant respiratory problems by 6 weeks (p = 0.010), as were LNF-II levels in infant feces (p = 0.003). LNF-II levels in milk at 2 weeks were also associated with fewer respiratory problems by 12 weeks (p = 0.038), and fewer enteric problems by 6 weeks (p = 0.004) and 12 weeks (p = 0.045). Thus, consumption of human milk oligosaccharides through breastfeeding, represented by LNF-II, was associated with less reported respiratory and gastrointestinal illness in infants.
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U2 - 10.1089/bfm.2006.1.207
DO - 10.1089/bfm.2006.1.207
M3 - Article
C2 - 17661601
AN - SCOPUS:34548504341
SN - 1556-8253
VL - 1
SP - 207
EP - 215
JO - Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine
JF - Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine
IS - 4
ER -