@inbook{e18874c2f3b447088d746b5fd19601b4,
title = "Early life stress and susceptibility to addiction in adolescence",
abstract = "Early life stress (ELS) is a risk factor for developing a host of psychiatric disorders. Adolescence is a particularly vulnerable period for the onset of these disorders and substance use disorders (SUDs). Here we discuss ELS and its effects in adolescence, especially SUDs, and their correlates with molecular changes to signaling systems in reward and stress neurocircuits. Using a maternal separation (MS) model of neonatal ELS, we studied a range of behaviors that comprise a “drug-seeking” phenotype. We then investigated potential mechanisms underlying the development of this phenotype. Corticotropin releasing factor (CRF) and serotonin (5-HT) are widely believed to be involved in “stress-induced” disorders, including addiction. Here, we show that ELS leads to the development of a drug-seeking phenotype indicative of increased susceptibility to addiction and concomitant sex-dependent upregulation of CRF and 5-HT system components throughout extended brain reward/stress neurocircuits.",
keywords = "Addiction, Adolescence, Corticotropin releasing factor, Drug-seeking, Early life stress, Maternal separation, Serotonin, Stress",
author = "Tschetter, {K. E.} and Callahan, {L. B.} and Flynn, {S. A.} and S. Rahman and Beresford, {T. P.} and Ronan, {P. J.}",
note = "Funding Information: This work was supported with funding from a Department of Veterans Affairs Merit Review Award 1 I01 BX004712 (P.J.R. T.P.B.), NIMH 1 R01 MH122954 (P.J.R.), NIH NCRR P20 RR015567 (P.J.R.), NIH NIGMS U54GM128729 (P.J.R.), Great Plains Veterans Research Foundation (P.J.R.), and the Avera Foundation (P.J.R. S.R.). The authors further acknowledge the Sioux Falls VA Healthcare System for their generous research support. We would like to thank Drs. Jason Petersen, Karen Munger, David Maddox, and Cliff Summers for thoughtful discussions and reviews of this manuscript. The contents of this manuscript do not represent the views of the Department of Veterans Affairs or the United States Government. The authors declare that they have no conflict of interest. Funding Information: This work was supported with funding from a Department of Veterans Affairs Merit Re- view Award 1 I01 BX004712 (P.J.R., T.P.B.), NIMH 1 R01 MH122954 (P.J.R.), NIH NCRR P20 RR015567 (P.J.R.), NIH NIGMS U54GM128729 (P.J.R.), Great Plains Veterans Research Foundation (P.J.R.), and the Avera Foundation (P.J.R., S.R.). The authors further acknowledge the Sioux Falls VA Healthcare System for their generous research support. We would like to thank Drs. Jason Petersen, Karen Munger, David Maddox, and Cliff Summers for thoughtful discussions and reviews of this manuscript. The contents of this manuscript do not represent the views of the Department of Veterans Affairs or the United States Government. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",
year = "2022",
month = jan,
doi = "10.1016/bs.irn.2021.08.007",
language = "English (US)",
isbn = "9780323992602",
series = "International Review of Neurobiology",
publisher = "Academic Press Inc.",
pages = "277--302",
editor = "Bell, {Richard L.} and Shafiqur Rahman",
booktitle = "Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS Part II",
}