Ebola virus transmission initiated by relapse of systemic Ebola virus disease

Placide Mbala-Kingebeni; Catherine Pratt; Mbusa Mutafali-Ruffin; Matthias G. Pauthner; Faustin Bile; Antoine Nkuba-Ndaye; Allison Black; Eddy Kinganda-Lusamaki; Martin Faye; Amuri Aziza; Moussa M. Diagne; Daniel Mukadi; Bailey White; James Hadfield; Karthik Gangavarapu; Nella Bisento; Donatien Kazadi; Bibiche Nsunda; Marceline Akonga; Olivier Tshiani; John Misasi; Aurelie Ploquin; Victor Epaso; Emilia Sana-Paka; Yannick Tutu Tshia N’kasar; Fabrice Mambu; Francois Edidi; Meris Matondo; Junior Bula Bula; Boubacar Diallo; Mory Keita; Marie R.D. Belizaire; Ibrahima S. Fall; Abdoulaye Yam; Sabue Mulangu; Anne W. Rimion; Elias Salfati; Ali Torkamani; Marc A. Suchard; Ian Crozier; Lisa Hensley; Andrew Rambaut; Ousmane Faye; Amadou Sall; Nancy J. Sullivan; Trevor Bedford; Kristian G. Andersen; Michael R. Wiley; Steve Ahuka-Mundeke; Jean Jacques Muyembe Tamfum

doi:10.1056/NEJMoa2024670

Ebola virus transmission initiated by relapse of systemic Ebola virus disease

Placide Mbala-Kingebeni, Catherine Pratt, Mbusa Mutafali-Ruffin, Matthias G. Pauthner, Faustin Bile, Antoine Nkuba-Ndaye, Allison Black, Eddy Kinganda-Lusamaki, Martin Faye, Amuri Aziza, Moussa M. Diagne, Daniel Mukadi, Bailey White, James Hadfield, Karthik Gangavarapu, Nella Bisento, Donatien Kazadi, Bibiche Nsunda, Marceline Akonga, Olivier TshianiJohn Misasi, Aurelie Ploquin, Victor Epaso, Emilia Sana-Paka, Yannick Tutu Tshia N’kasar, Fabrice Mambu, Francois Edidi, Meris Matondo, Junior Bula Bula, Boubacar Diallo, Mory Keita, Marie R.D. Belizaire, Ibrahima S. Fall, Abdoulaye Yam, Sabue Mulangu, Anne W. Rimion, Elias Salfati, Ali Torkamani, Marc A. Suchard, Ian Crozier, Lisa Hensley, Andrew Rambaut, Ousmane Faye, Amadou Sall, Nancy J. Sullivan, Trevor Bedford, Kristian G. Andersen, Michael R. Wiley, Steve Ahuka-Mundeke, Jean Jacques Muyembe Tamfum

Environmental, Agricultural & Occupational Health Sciences

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

During the 2018–2020 Ebola virus disease (EVD) outbreak in North Kivu province in the Democratic Republic of Congo, EVD was diagnosed in a patient who had received the recombinant vesicular stomatitis virus–based vaccine expressing a ZEBOV glycoprotein (rVSV-ZEBOV) (Merck). His treatment included an Ebola virus (EBOV)–specific monoclonal antibody (mAb114), and he recovered within 14 days. However, 6 months later, he presented again with severe EVD-like illness and EBOV viremia, and he died. We initiated epidemiologic and genomic investigations that showed that the patient had had a relapse of acute EVD that led to a transmission chain resulting in 91 cases across six health zones over 4 months. (Funded by the Bill and Melinda Gates Foundation and others.)

Original language	English (US)
Pages (from-to)	1240-1247
Number of pages	8
Journal	New England Journal of Medicine
Volume	384
Issue number	13
DOIs	https://doi.org/10.1056/NEJMoa2024670
State	Published - Apr 1 2021

ASJC Scopus subject areas

Medicine(all)

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10.1056/NEJMoa2024670

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Mbala-Kingebeni, P., Pratt, C., Mutafali-Ruffin, M., Pauthner, M. G., Bile, F., Nkuba-Ndaye, A., Black, A., Kinganda-Lusamaki, E., Faye, M., Aziza, A., Diagne, M. M., Mukadi, D., White, B., Hadfield, J., Gangavarapu, K., Bisento, N., Kazadi, D., Nsunda, B., Akonga, M., ... Tamfum, J. J. M. (2021). Ebola virus transmission initiated by relapse of systemic Ebola virus disease. New England Journal of Medicine, 384(13), 1240-1247. https://doi.org/10.1056/NEJMoa2024670

Mbala-Kingebeni, P, Pratt, C, Mutafali-Ruffin, M, Pauthner, MG, Bile, F, Nkuba-Ndaye, A, Black, A, Kinganda-Lusamaki, E, Faye, M, Aziza, A, Diagne, MM, Mukadi, D, White, B, Hadfield, J, Gangavarapu, K, Bisento, N, Kazadi, D, Nsunda, B, Akonga, M, Tshiani, O, Misasi, J, Ploquin, A, Epaso, V, Sana-Paka, E, N’kasar, YTT, Mambu, F, Edidi, F, Matondo, M, Bula, JB, Diallo, B, Keita, M, Belizaire, MRD, Fall, IS, Yam, A, Mulangu, S, Rimion, AW, Salfati, E, Torkamani, A, Suchard, MA, Crozier, I, Hensley, L, Rambaut, A, Faye, O, Sall, A, Sullivan, NJ, Bedford, T, Andersen, KG, Wiley, MR, Ahuka-Mundeke, S & Tamfum, JJM 2021, 'Ebola virus transmission initiated by relapse of systemic Ebola virus disease', New England Journal of Medicine, vol. 384, no. 13, pp. 1240-1247. https://doi.org/10.1056/NEJMoa2024670

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title = "Ebola virus transmission initiated by relapse of systemic Ebola virus disease",

abstract = "During the 2018–2020 Ebola virus disease (EVD) outbreak in North Kivu province in the Democratic Republic of Congo, EVD was diagnosed in a patient who had received the recombinant vesicular stomatitis virus–based vaccine expressing a ZEBOV glycoprotein (rVSV-ZEBOV) (Merck). His treatment included an Ebola virus (EBOV)–specific monoclonal antibody (mAb114), and he recovered within 14 days. However, 6 months later, he presented again with severe EVD-like illness and EBOV viremia, and he died. We initiated epidemiologic and genomic investigations that showed that the patient had had a relapse of acute EVD that led to a transmission chain resulting in 91 cases across six health zones over 4 months. (Funded by the Bill and Melinda Gates Foundation and others.)",

author = "Placide Mbala-Kingebeni and Catherine Pratt and Mbusa Mutafali-Ruffin and Pauthner, {Matthias G.} and Faustin Bile and Antoine Nkuba-Ndaye and Allison Black and Eddy Kinganda-Lusamaki and Martin Faye and Amuri Aziza and Diagne, {Moussa M.} and Daniel Mukadi and Bailey White and James Hadfield and Karthik Gangavarapu and Nella Bisento and Donatien Kazadi and Bibiche Nsunda and Marceline Akonga and Olivier Tshiani and John Misasi and Aurelie Ploquin and Victor Epaso and Emilia Sana-Paka and N{\textquoteright}kasar, {Yannick Tutu Tshia} and Fabrice Mambu and Francois Edidi and Meris Matondo and Bula, {Junior Bula} and Boubacar Diallo and Mory Keita and Belizaire, {Marie R.D.} and Fall, {Ibrahima S.} and Abdoulaye Yam and Sabue Mulangu and Rimion, {Anne W.} and Elias Salfati and Ali Torkamani and Suchard, {Marc A.} and Ian Crozier and Lisa Hensley and Andrew Rambaut and Ousmane Faye and Amadou Sall and Sullivan, {Nancy J.} and Trevor Bedford and Andersen, {Kristian G.} and Wiley, {Michael R.} and Steve Ahuka-Mundeke and Tamfum, {Jean Jacques Muyembe}",

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year = "2021",

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doi = "10.1056/NEJMoa2024670",

language = "English (US)",

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T1 - Ebola virus transmission initiated by relapse of systemic Ebola virus disease

AU - Mbala-Kingebeni, Placide

AU - Pratt, Catherine

AU - Mutafali-Ruffin, Mbusa

AU - Pauthner, Matthias G.

AU - Bile, Faustin

AU - Nkuba-Ndaye, Antoine

AU - Black, Allison

AU - Kinganda-Lusamaki, Eddy

AU - Faye, Martin

AU - Aziza, Amuri

AU - Diagne, Moussa M.

AU - Mukadi, Daniel

AU - White, Bailey

AU - Hadfield, James

AU - Gangavarapu, Karthik

AU - Bisento, Nella

AU - Kazadi, Donatien

AU - Nsunda, Bibiche

AU - Akonga, Marceline

AU - Tshiani, Olivier

AU - Misasi, John

AU - Ploquin, Aurelie

AU - Epaso, Victor

AU - Sana-Paka, Emilia

AU - N’kasar, Yannick Tutu Tshia

AU - Mambu, Fabrice

AU - Edidi, Francois

AU - Matondo, Meris

AU - Bula, Junior Bula

AU - Diallo, Boubacar

AU - Keita, Mory

AU - Belizaire, Marie R.D.

AU - Fall, Ibrahima S.

AU - Yam, Abdoulaye

AU - Mulangu, Sabue

AU - Rimion, Anne W.

AU - Salfati, Elias

AU - Torkamani, Ali

AU - Suchard, Marc A.

AU - Crozier, Ian

AU - Hensley, Lisa

AU - Rambaut, Andrew

AU - Faye, Ousmane

AU - Sall, Amadou

AU - Sullivan, Nancy J.

AU - Bedford, Trevor

AU - Andersen, Kristian G.

AU - Wiley, Michael R.

AU - Ahuka-Mundeke, Steve

AU - Tamfum, Jean Jacques Muyembe

PY - 2021/4/1

Y1 - 2021/4/1

N2 - During the 2018–2020 Ebola virus disease (EVD) outbreak in North Kivu province in the Democratic Republic of Congo, EVD was diagnosed in a patient who had received the recombinant vesicular stomatitis virus–based vaccine expressing a ZEBOV glycoprotein (rVSV-ZEBOV) (Merck). His treatment included an Ebola virus (EBOV)–specific monoclonal antibody (mAb114), and he recovered within 14 days. However, 6 months later, he presented again with severe EVD-like illness and EBOV viremia, and he died. We initiated epidemiologic and genomic investigations that showed that the patient had had a relapse of acute EVD that led to a transmission chain resulting in 91 cases across six health zones over 4 months. (Funded by the Bill and Melinda Gates Foundation and others.)

AB - During the 2018–2020 Ebola virus disease (EVD) outbreak in North Kivu province in the Democratic Republic of Congo, EVD was diagnosed in a patient who had received the recombinant vesicular stomatitis virus–based vaccine expressing a ZEBOV glycoprotein (rVSV-ZEBOV) (Merck). His treatment included an Ebola virus (EBOV)–specific monoclonal antibody (mAb114), and he recovered within 14 days. However, 6 months later, he presented again with severe EVD-like illness and EBOV viremia, and he died. We initiated epidemiologic and genomic investigations that showed that the patient had had a relapse of acute EVD that led to a transmission chain resulting in 91 cases across six health zones over 4 months. (Funded by the Bill and Melinda Gates Foundation and others.)

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U2 - 10.1056/NEJMoa2024670

DO - 10.1056/NEJMoa2024670

M3 - Article

C2 - 33789012

AN - SCOPUS:85103600163

SN - 0028-4793

VL - 384

SP - 1240

EP - 1247

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 13

ER -

Ebola virus transmission initiated by relapse of systemic Ebola virus disease

Abstract

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