Eccrine syringofibroadenoma surrounding a squamous cell carcinoma: A case report

Subodh M. Lele, Elizabeth S. Gloster, Edward R. Heilman, Patrick C. Chen, Chun Kuo Chen, Archinto P. Anzil, Jason N. Pozner, Michael J. Reardon

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


A 91-year-old man presented with a 9.0 x 7.0 cm exophytic mass on the dorsum of the right foot, surrounded by a scaling hyperkeratotic plaque-like lesion that had been present for many years. He had similar long-standing hyperkeratotic plaque-like lesions on both legs. Histopathologic examination of the exophytic mass revealed a well-differentiated squamous cell carcinoma surrounded by an eccrine syringofibroadenoma (ESFA). Histochemistry, immunohistochemistry and electron microscopy support this diagnosis. To our knowledge, this is the only reported case of ESFA being intimately associated with a malignant neoplasm.

Original languageEnglish (US)
Pages (from-to)193-196
Number of pages4
JournalJournal of Cutaneous Pathology
Issue number3
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology


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