Abstract
Gutierrez-Perez et al. show that BTB domain-containing isoforms of Pipsqueak associate with architectural proteins, whereas Psq lacking BTB colocalizes with Polycomb. Induction of differentiation by the hormone 20-hydroxyecdysone results in recruitment of the ecdysone receptor and Psq lacking BTB to enhancers and establishment of interactions with promoters of activated genes.
Original language | English (US) |
---|---|
Pages (from-to) | 2715-2727.e5 |
Journal | Cell Reports |
Volume | 28 |
Issue number | 10 |
DOIs | |
State | Published - Sep 3 2019 |
Externally published | Yes |
Keywords
- CTCF
- GAF
- HiChIP
- POZ/BTB
- Pipsqueak
- architectural protein
- chromatin
- epigenetics
- hormone
- transcription
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology