Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb

Irene Gutierrez-Perez, M. Jordan Rowley, Xiaowen Lyu, Viviana Valadez-Graham, Diana M. Vallejo, Esther Ballesta-Illan, Jose P. Lopez-Atalaya, Isaac Kremsky, Esther Caparros, Victor G. Corces, Maria Dominguez

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Gutierrez-Perez et al. show that BTB domain-containing isoforms of Pipsqueak associate with architectural proteins, whereas Psq lacking BTB colocalizes with Polycomb. Induction of differentiation by the hormone 20-hydroxyecdysone results in recruitment of the ecdysone receptor and Psq lacking BTB to enhancers and establishment of interactions with promoters of activated genes.

Original languageEnglish (US)
Pages (from-to)2715-2727.e5
JournalCell Reports
Volume28
Issue number10
DOIs
StatePublished - Sep 3 2019

Keywords

  • CTCF
  • GAF
  • HiChIP
  • POZ/BTB
  • Pipsqueak
  • architectural protein
  • chromatin
  • epigenetics
  • hormone
  • transcription

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb'. Together they form a unique fingerprint.

Cite this