Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb

Irene Gutierrez-Perez; M. Jordan Rowley; Xiaowen Lyu; Viviana Valadez-Graham; Diana M. Vallejo; Esther Ballesta-Illan; Jose P. Lopez-Atalaya; Isaac Kremsky; Esther Caparros; Victor G. Corces; Maria Dominguez

doi:10.1016/j.celrep.2019.07.096

Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb

Irene Gutierrez-Perez, M. Jordan Rowley, Xiaowen Lyu, Viviana Valadez-Graham, Diana M. Vallejo, Esther Ballesta-Illan, Jose P. Lopez-Atalaya, Isaac Kremsky, Esther Caparros, Victor G. Corces, Maria Dominguez

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Gutierrez-Perez et al. show that BTB domain-containing isoforms of Pipsqueak associate with architectural proteins, whereas Psq lacking BTB colocalizes with Polycomb. Induction of differentiation by the hormone 20-hydroxyecdysone results in recruitment of the ecdysone receptor and Psq lacking BTB to enhancers and establishment of interactions with promoters of activated genes.

Original language	English (US)
Pages (from-to)	2715-2727.e5
Journal	Cell Reports
Volume	28
Issue number	10
DOIs	https://doi.org/10.1016/j.celrep.2019.07.096
State	Published - Sep 3 2019
Externally published	Yes

Keywords

CTCF
GAF
HiChIP
POZ/BTB
Pipsqueak
architectural protein
chromatin
epigenetics
hormone
transcription

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2019.07.096

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Gutierrez-Perez, I., Rowley, M. J., Lyu, X., Valadez-Graham, V., Vallejo, D. M., Ballesta-Illan, E., Lopez-Atalaya, J. P., Kremsky, I., Caparros, E., Corces, V. G., & Dominguez, M. (2019). Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb. Cell Reports, 28(10), 2715-2727.e5. https://doi.org/10.1016/j.celrep.2019.07.096

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abstract = "Gutierrez-Perez et al. show that BTB domain-containing isoforms of Pipsqueak associate with architectural proteins, whereas Psq lacking BTB colocalizes with Polycomb. Induction of differentiation by the hormone 20-hydroxyecdysone results in recruitment of the ecdysone receptor and Psq lacking BTB to enhancers and establishment of interactions with promoters of activated genes.",

keywords = "CTCF, GAF, HiChIP, POZ/BTB, Pipsqueak, architectural protein, chromatin, epigenetics, hormone, transcription",

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doi = "10.1016/j.celrep.2019.07.096",

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AU - Gutierrez-Perez, Irene

AU - Rowley, M. Jordan

AU - Lyu, Xiaowen

AU - Valadez-Graham, Viviana

AU - Vallejo, Diana M.

AU - Ballesta-Illan, Esther

AU - Lopez-Atalaya, Jose P.

AU - Kremsky, Isaac

AU - Caparros, Esther

AU - Corces, Victor G.

AU - Dominguez, Maria

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AB - Gutierrez-Perez et al. show that BTB domain-containing isoforms of Pipsqueak associate with architectural proteins, whereas Psq lacking BTB colocalizes with Polycomb. Induction of differentiation by the hormone 20-hydroxyecdysone results in recruitment of the ecdysone receptor and Psq lacking BTB to enhancers and establishment of interactions with promoters of activated genes.

KW - CTCF

KW - GAF

KW - HiChIP

KW - POZ/BTB

KW - Pipsqueak

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KW - chromatin

KW - epigenetics

KW - hormone

KW - transcription

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Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb

Abstract

Keywords

ASJC Scopus subject areas

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