Effect of a platelet-activating factor antagonist and desferrioxamine administration on eicosanoid production in rat pancreas transplantation

Felip Pi, Georgina Hotter, Daniel Closa, Joan Roselló-Catafau, Oriol Bulbena, Francesc Badosa, Michael Morris, Laureano Fernández-Cruz, Emilio Gelpí

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Eicosanoid metabolism and its relationship with platelet-activating factor and oxygen free radical production in rat pancreas transplantation has been studied herein. Male Sprague-Dawley rats were classified in 4 experimental groups (n=8 each) as follows: group 1, control; group 2, pancreas transplantation, after 12 hr of organ preservation in University of Wisconsin solution; group 3, same as group 2 with desferrioxamine administration before revascularization of the organ in the recipient rat; and group 4, same as group 3 with administration of a platelet-activating factor antagonist (BN-52021). The results show posttransplantation increases in eicosanoid production in pancreatic tissue. The fact that desferrioxamine and BN-52021 administration could reverse increases in thromboxane B2, leukotriene B4, and 12-hydroxyeicosatetraenoic acid but only BN-52021 affected 6-keto-PGF levels suggests the existence of a close relationship between platelet-activating factor and oxygen free radical in eicosanoid production in pancreas transplantation and it points to a differential role of metabolites produced by circulatory cells and endothelial cells.

Original languageEnglish (US)
Pages (from-to)12-17
Number of pages6
JournalTransplantation
Volume57
Issue number1
DOIs
StatePublished - Jan 1994

ASJC Scopus subject areas

  • Transplantation

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    Pi, F., Hotter, G., Closa, D., Roselló-Catafau, J., Bulbena, O., Badosa, F., Morris, M., Fernández-Cruz, L., & Gelpí, E. (1994). Effect of a platelet-activating factor antagonist and desferrioxamine administration on eicosanoid production in rat pancreas transplantation. Transplantation, 57(1), 12-17. https://doi.org/10.1097/00007890-199401000-00003