TY - JOUR
T1 - Effect of afferent renal nerve stimulation on blood pressure, heart rate and noradrenergic activity in conscious rats
AU - Patel, K. P.
AU - Knuepfer, M. M.
N1 - Funding Information:
The authors are grateful for, the excellent technical assistance of Dr. K.Y. Chow, research facilities provided by Dr. R.L. Kline for these experiments, and helpful suggestions of Dr. R.L. Kline, Dr. F.R. Calaresu, and Dr. P.G. Schmid. M.M.K. was supported by NIH HL 06336.
PY - 1986/10
Y1 - 1986/10
N2 - The effects of electrical stimulation of afferent renal nerves on arterial pressure, heart rate, and α-methyltyrosine-induced disappearance of norepinephrine in the hypothalamus, contralateral kidney, intestine, and skeletal muscle were studied in conscious rats. There was a significant increase in arterial pressure in response to afferent renal nerve stimulation. There was no significant change in the turnover of norepinephrine in the hypothalamus. However, there was a significant increase in the turnover of norepinephrine in the skeletal muscle, a tendency toward an increase in the intestine, and no change in the contralateral kidney. These results indicate that activation of afferent renal nerve fibers does not change noradrenergic activity in the hypothalamus yet produces a differential sympathetic outflow. Secondly, the increased turnover of norepinephrine in skeletal muscle may be contributing to.
AB - The effects of electrical stimulation of afferent renal nerves on arterial pressure, heart rate, and α-methyltyrosine-induced disappearance of norepinephrine in the hypothalamus, contralateral kidney, intestine, and skeletal muscle were studied in conscious rats. There was a significant increase in arterial pressure in response to afferent renal nerve stimulation. There was no significant change in the turnover of norepinephrine in the hypothalamus. However, there was a significant increase in the turnover of norepinephrine in the skeletal muscle, a tendency toward an increase in the intestine, and no change in the contralateral kidney. These results indicate that activation of afferent renal nerve fibers does not change noradrenergic activity in the hypothalamus yet produces a differential sympathetic outflow. Secondly, the increased turnover of norepinephrine in skeletal muscle may be contributing to.
KW - Afferent renal nerve
KW - Blood pressure
KW - Noradrenergic activity
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U2 - 10.1016/0165-1838(86)90087-1
DO - 10.1016/0165-1838(86)90087-1
M3 - Article
C2 - 2878017
AN - SCOPUS:0022501545
SN - 1566-0702
VL - 17
SP - 121
EP - 130
JO - Journal of the Autonomic Nervous System
JF - Journal of the Autonomic Nervous System
IS - 2
ER -