Effect of age on intestinal regeneration in the rabbit

Jon S. Thompson; Shailendra K. Saxena; John G. Sharp

doi:10.1016/0047-6374(90)90134-2

Effect of age on intestinal regeneration in the rabbit

Jon S. Thompson, Shailendra K. Saxena, John G. Sharp

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We compared the rate of regeneration of full thickness serosa patched intestinal defects to determine whether this regenerative process is influenced by age. Twenty-five rabbits aged 3, 9, 15, 36 and 60 months were killed 3 weeks after patching. Epithelialization was slightly but significantly greater in the 3-month-old rabbits but there were no differences in contraction of the patched defect or villus development of the regenerating mucosa. Disaccharidase activity was greatest in the older animals but glucose uptake was similar at all ages. Proliferative activity was similar as well. Thus, intestinal regeneration in full thickness intestinal defects does not appear to be influenced significantly by the age of the animals.

Original language	English (US)
Pages (from-to)	305-312
Number of pages	8
Journal	Mechanisms of Ageing and Development
Volume	52
Issue number	2-3
DOIs	https://doi.org/10.1016/0047-6374(90)90134-2
State	Published - Mar 15 1990

Keywords

Aging
Intestinal injury
Small intestine

ASJC Scopus subject areas

Aging
Developmental Biology

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10.1016/0047-6374(90)90134-2

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title = "Effect of age on intestinal regeneration in the rabbit",

abstract = "We compared the rate of regeneration of full thickness serosa patched intestinal defects to determine whether this regenerative process is influenced by age. Twenty-five rabbits aged 3, 9, 15, 36 and 60 months were killed 3 weeks after patching. Epithelialization was slightly but significantly greater in the 3-month-old rabbits but there were no differences in contraction of the patched defect or villus development of the regenerating mucosa. Disaccharidase activity was greatest in the older animals but glucose uptake was similar at all ages. Proliferative activity was similar as well. Thus, intestinal regeneration in full thickness intestinal defects does not appear to be influenced significantly by the age of the animals.",

keywords = "Aging, Intestinal injury, Small intestine",

author = "Thompson, {Jon S.} and Saxena, {Shailendra K.} and Sharp, {John G.}",

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T1 - Effect of age on intestinal regeneration in the rabbit

AU - Thompson, Jon S.

AU - Saxena, Shailendra K.

AU - Sharp, John G.

N1 - Funding Information: This work was supportedb y Grant DK36612 from the NationalI nstituteo f Health.

PY - 1990/3/15

Y1 - 1990/3/15

N2 - We compared the rate of regeneration of full thickness serosa patched intestinal defects to determine whether this regenerative process is influenced by age. Twenty-five rabbits aged 3, 9, 15, 36 and 60 months were killed 3 weeks after patching. Epithelialization was slightly but significantly greater in the 3-month-old rabbits but there were no differences in contraction of the patched defect or villus development of the regenerating mucosa. Disaccharidase activity was greatest in the older animals but glucose uptake was similar at all ages. Proliferative activity was similar as well. Thus, intestinal regeneration in full thickness intestinal defects does not appear to be influenced significantly by the age of the animals.

AB - We compared the rate of regeneration of full thickness serosa patched intestinal defects to determine whether this regenerative process is influenced by age. Twenty-five rabbits aged 3, 9, 15, 36 and 60 months were killed 3 weeks after patching. Epithelialization was slightly but significantly greater in the 3-month-old rabbits but there were no differences in contraction of the patched defect or villus development of the regenerating mucosa. Disaccharidase activity was greatest in the older animals but glucose uptake was similar at all ages. Proliferative activity was similar as well. Thus, intestinal regeneration in full thickness intestinal defects does not appear to be influenced significantly by the age of the animals.

KW - Aging

KW - Intestinal injury

KW - Small intestine

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Effect of age on intestinal regeneration in the rabbit

Abstract

Keywords

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