Effect of albumin microinfusion on proximal tubular pressure

Pamela K. Carmines, George A. Tanner

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The present study tested the idea that protein in tubular fluid is responsible for an increase in resistance of Henle’s loops in the nephrotic syndrome. Single proximal tubules of anesthetized, normal rats were microinfused with an isotonic equilibrium solution containing 0–250 mg/100 ml bovine serum albumin while proximal tubular pressure (PTP) was continuously recorded. Microinfusion at 16 and 40 nl/min produced significant (p < 0.01) increments in PTP. There was no significant effect (p > 0.50) of albumin. These results suggest that moderate concentrations of albumin in tubular fluid do not cause an increase in resistance to tubular fluid flow.

Original languageEnglish (US)
Pages (from-to)85-87
Number of pages3
JournalKidney and Blood Pressure Research
Volume5
Issue number2
DOIs
StatePublished - 1982

Keywords

  • Kidney tubule microinfusion
  • Nephrotic syndrome
  • Proximal tubular pressure

ASJC Scopus subject areas

  • Nephrology
  • Cardiology and Cardiovascular Medicine

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