Effect of aldose reductase inhibitors on the progression of retinopathy in galactose-fed dogs

Yoshio Akagi, Peter F. Kador

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The onset and progression of diabetic-like retinopathy has been investigated in age-matched male beagle dogs fed a 30% galactose diet. Examination of the intact retinal vessels, isolated by gentle trypsin digestion, reveals that the destruction of pericytes to form pericyte ghosts is the earliest observable retinal vessel change. This results in an irregular distribution of endothelial cell nuclei near pericyte ghosts and the subsequent formation of acellular capillaries containing neither endothelial cells or pericytes. This was followed by the histological appearance of microaneurysms and later, by the funduscopic appearance of intraretinal hemorrhages. Studies in similar galactose-fed dogs treated with aldose reductase inhibitors indicate that all of these changes are linked to the initial aldose reductase associated destruction of pericytes.

Original languageEnglish (US)
Pages (from-to)635-639
Number of pages5
JournalExperimental Eye Research
Volume50
Issue number6
DOIs
StatePublished - Jun 1990

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Keywords

  • aldose reductase
  • aldose reductase inhibitors
  • diabetes
  • endothelial cells
  • galactosemia
  • pericytes
  • retinopathy

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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