Effect of an anti-oestrogen on implantation of mouse blastocysts

J. Sengupta, S. K. Roy, S. K. Manchanda

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Mouse blastocysts collected on Day 4 were cultured for 4 h in Whitten's medium containing in 5 μg CI-628 citrate, a specific estrogen antagonist, and transferred to the uteri of pseudopregnant hosts. There was a significant reduction in the number of implantations observed on Day 11 when compared with those from blastocysts which were similarly transferred after culture in medium alone or in medium containing 1 μg estradiol 17β and 5 μg CI-628 citrate. We suggest that this is further evidence for the involvement of embryonic estrogen in implantation.

Original languageEnglish (US)
Pages (from-to)433-436
Number of pages4
JournalJournal of reproduction and fertility
Issue number2
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Embryology
  • Molecular Biology
  • Obstetrics and Gynecology
  • Developmental Biology

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