TY - JOUR
T1 - Effect of Balloon Valvuloplasty in Patients With Severe Aortic Stenosis on Levels of N-Terminal Pro-B-Type Natriuretic Peptide
AU - Spargias, Konstantinos
AU - Alexopoulos, Elias
AU - Thomopoulou, Sofia
AU - Dimopoulos, Antonis
AU - Manginas, Athanasios
AU - Pavlides, Gregory
AU - Voudris, Vassilis
AU - Karatassakis, George
AU - Athanassopoulos, George
AU - Cokkinos, Dennis V.
PY - 2009/9/15
Y1 - 2009/9/15
N2 - Plasma levels of brain natriuretic peptide (BNP) have been shown to correlate to aortic stenosis severity and are predictive of symptom development and survival. They also predict postoperative outcomes after valve replacement in patients with aortic stenosis. The early evolution of N-terminal-pro-BNP (NT-pro-BNP) levels after 50 aortic balloon valvuloplasty procedures performed in 45 patients was investigated. The mean NT-pro-BNP concentration decreased from 7,048 ± 7,636 pg/ml at baseline to 5,309 ± 6,150 pg/ml at 1 to 3 days after the procedure (mean difference 1,739 pg/ml, 95% confidence interval 804 to 2,675, p = 0.001). The absolute reduction in NT-pro-BNP levels correlated to the reductions in the maximum and mean transvalvular pressure gradients (on echocardiography: c = 0.57, p = 0.004, and c = 0.54, p = 0.012, respectively; invasively: c = 0.54, p = 0.025, and c = 0.39, p = 0.019). In conclusion, NT-pro-BNP levels decrease early after aortic balloon valvuloplasty in patients with severe aortic stenosis at high surgical risk.
AB - Plasma levels of brain natriuretic peptide (BNP) have been shown to correlate to aortic stenosis severity and are predictive of symptom development and survival. They also predict postoperative outcomes after valve replacement in patients with aortic stenosis. The early evolution of N-terminal-pro-BNP (NT-pro-BNP) levels after 50 aortic balloon valvuloplasty procedures performed in 45 patients was investigated. The mean NT-pro-BNP concentration decreased from 7,048 ± 7,636 pg/ml at baseline to 5,309 ± 6,150 pg/ml at 1 to 3 days after the procedure (mean difference 1,739 pg/ml, 95% confidence interval 804 to 2,675, p = 0.001). The absolute reduction in NT-pro-BNP levels correlated to the reductions in the maximum and mean transvalvular pressure gradients (on echocardiography: c = 0.57, p = 0.004, and c = 0.54, p = 0.012, respectively; invasively: c = 0.54, p = 0.025, and c = 0.39, p = 0.019). In conclusion, NT-pro-BNP levels decrease early after aortic balloon valvuloplasty in patients with severe aortic stenosis at high surgical risk.
UR - http://www.scopus.com/inward/record.url?scp=69549106511&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69549106511&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2009.05.013
DO - 10.1016/j.amjcard.2009.05.013
M3 - Article
C2 - 19733722
AN - SCOPUS:69549106511
SN - 0002-9149
VL - 104
SP - 846
EP - 849
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 6
ER -